alexa Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)- Quinazolinone Derivatives | OMICS International| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Curr Res 2013, Vol 2(2): 118
  • DOI: 10.4172/2161-0401.1000118

Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)- Quinazolinone Derivatives

Natvar A Sojitra1, Rajesh K Patel3, Ritu B Dixit2 and Bharat C Dixit1*
1Chemistry Department, V. P. & R. P. T. P. Science College, Affiliated to Sardar Patel University, Gujarat, India
2Ashok & Rita Patel Institute of Integrated Studies and Research in Biotechnology and Allied Sciences, Gujarat, India
3Department of Life Sciences, Hemchandracharya North Gujarat University, Gujarat, India
*Corresponding Author : Bharat C Dixit, Chemistry Department, V. P. & R. P. T. P. Science College, Affiliated to Sardar Patel University, VallabhVidyangar– 388 120, Anand, Gujarat, India, Email: [email protected]

Received Date: May 03, 2013 / Accepted Date: Jul 26, 2013 / Published Date: Jul 29, 2013

Abstract

A series of structurally diverse and newly designed pyrimidinone substituted 4(3H)-Quinazolinone derivatives 6a–6j were synthesized in a simple and facile manner under both conventional and microwave heating conditions. Entitled compounds 6a–6j were synthesized using N-acylanthranilic acid derivatives 1a–1j and hydrazinylbenzenesulfonamide2 as a key starting materials, which under goes hierarchy of the reactions via different intermediate steps; quinazolinone derivatives 3a–3j and hydrazonoquinazolinone derivatives 5a–5j. All the synthesized compounds are in good amount of yield. The structure of entitle compounds have been evaluated on the basis of various spectroscopic techniques and analytical methods as well as, all the synthesized compounds were subjected to in vitro antibacterial activities. Some of the compounds displayed moderate to good in vitro antimicrobial activity by broth micro dilution method against pathogenic bacteria (S. aureus,B. subtilis, B. megaterium, E. coli, P. vulgaris, P. aeruginosa) species.

Keywords: Quinazolinone; Pyrimidinone; Antimicrobial activity; Microwave heating

Citation: Sojitra NA, Patel RK, Dixit RB, Dixit BC (2013) Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)-Quinazolinone Derivatives. Organic Chem Curr Res 2: 118. Doi: 10.4172/2161-0401.1000118

Copyright: ©2013 Sojitra NA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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