alexa Synthesis and Antioxidant Activity of Novel Series of N
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Synthesis and Antioxidant Activity of Novel Series of Naphthoquinone Derivatives Attached to Benzothiophene Moiety

Moustafa A Gouda1,2*, Hadeer Fakhr Eldien1, Margret M Girges1 and Moged A Berghot1

1Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt

2Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, KSA

*Corresponding Author:
Moustafa A Gouda
Chemistry Department, Faculty of Science
Mansoura University, Mansoura 35516, Egypt
Tel: (+2050) 6432235
Fax: (+2050)2246781
E-mail: [email protected]

Received date: May 10, 2013; Accepted date: June 14, 2013; Published date: June 16, 2013

Citation: Gouda MA, Eldien HF, Girges MM, Berghot MA (2013) Synthesis and Antioxidant Activity of Novel Series of Naphthoquinone Derivatives Attached to Benzothiophene Moiety. Med chem 3:228-232. doi:10.4172/2161-0444.1000143

Copyright: © 2013 Gouda MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A series of aryl azonaphthoquinones 8a-e were obtained via coupling of the corresponding diazonium salts 7a-c with naphthoquinones 2 or 3 in pyridine. Moreover, treatment of 5 with 6a, b in ethanol containing potassium carbonate afforded the corresponding enaminones 9a, b, respectively. Furthermore, heating of 6a with 2-hydroxy-3-((piperidn- 1-yl)methyl)naphthalene-1,4-dione 10 in EtOH/AcOHor sodium 3,4-dihydro-3,4-dioxonaphthalene-1-sulphonate 1 in MeOH/H2O afforded the corresponding enaminones 11 and 12, respectively. The newly synthesized compounds were screened for their antioxidant activity. Compounds 8b 89.87, 9a (89.93%) and 9b (95.97%) exhibited promising activities. On the other hand compounds 8b, 9a, 9b, 11 and 12 have the ability to protect DNA from the damage induced by bleomycin.

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