Synthesis and Antioxidant Activity of Novel Series of Naphthoquinone Derivatives Attached to Benzothiophene MoietyMoustafa A Gouda1,2*, Hadeer Fakhr Eldien1, Margret M Girges1 and Moged A Berghot1
- *Corresponding Author:
- Moustafa A Gouda
Chemistry Department, Faculty of Science
Mansoura University, Mansoura 35516, Egypt
Tel: (+2050) 6432235
E-mail: [email protected]
Received date: May 10, 2013; Accepted date: June 14, 2013; Published date: June 16, 2013
Citation: Gouda MA, Eldien HF, Girges MM, Berghot MA (2013) Synthesis and Antioxidant Activity of Novel Series of Naphthoquinone Derivatives Attached to Benzothiophene Moiety. Med chem 3:228-232. doi:10.4172/2161-0444.1000143
Copyright: © 2013 Gouda MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A series of aryl azonaphthoquinones 8a-e were obtained via coupling of the corresponding diazonium salts 7a-c with naphthoquinones 2 or 3 in pyridine. Moreover, treatment of 5 with 6a, b in ethanol containing potassium carbonate afforded the corresponding enaminones 9a, b, respectively. Furthermore, heating of 6a with 2-hydroxy-3-((piperidn- 1-yl)methyl)naphthalene-1,4-dione 10 in EtOH/AcOHor sodium 3,4-dihydro-3,4-dioxonaphthalene-1-sulphonate 1 in MeOH/H2O afforded the corresponding enaminones 11 and 12, respectively. The newly synthesized compounds were screened for their antioxidant activity. Compounds 8b 89.87, 9a (89.93%) and 9b (95.97%) exhibited promising activities. On the other hand compounds 8b, 9a, 9b, 11 and 12 have the ability to protect DNA from the damage induced by bleomycin.