Synthesis and Biological Evaluation of 2-Aryl - 6, 7-Difluorophenyl-1,3,4- Oxadiazolo (3,2-a) (1,3,5)-Triazine-5-(6H,7H)-Thiones
Department of Applied Sciences, Chandigarh Engineering College, CGC, Landran, Mohali, Punjab, India
- *Corresponding Author:
- Kiran Mishra
Department of Applied Sciences, Chandigarh Engineering College
CGC, Landran, Mohali-140 307, Punjab, India
E-mail: [email protected]
Received Date: April 26, 2017; Accepted Date: May 02, 2017; Published Date: June 09, 2017
Citation: Mishra K (2017) Synthesis and Biological Evaluation of 2-Aryl - 6, 7-Difluorophenyl-1,3,4-Oxadiazolo (3,2-a) (1,3,5)-Triazine-5-(6H,7H)-Thiones. Chem Sci J 8: 153. doi: 10.4172/2150-3494.1000153
Copyright: © 2017 Mishra K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
2-Aryl-6,7-difluorofenyl-1,3,4-oxadiazolo (3,2-a) (1,3,5)- triazine-5-(6H,7H)- thiones (2a-j) have been orchestrated by the cyclo expansion of para-fluorophenyl 4 –fluoro phenyl isothiocynate and 2-(4-fluorobenzylidine) to (1a-j) 2-amino - 5-phenyl-1,3,4-oxadiazole in dry toluene all the integrated compounds were very much described by their elemental analysis and spectral data. The integrated compounds have been screened for their antifungal action against Phytophthora infestans and Colletotrichum falcatum. Results demonstrated that greatest antifungal activity was appeared by the compounds 2b, 2c, 2g and 2h. These compounds demonstrated 99%, 98%, 99% and 97% hindrance of Phytophthora infestans and 97%, 96%, 98% and 97% Colletotrichum falcatum at 1000 ppm respectively.