alexa Synthesis and Characterization of and#945;,and#945;-Dimethyl-4-[1-Hydroxy-4-[4-(Hydroxyldiphenyl- Methyl)-1-Piperidinyl]Butyl] Benzeneacetic Acid Metal Complexes of Biological Interest | Abstract
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Synthesis and Characterization of α,α-Dimethyl-4-[1-Hydroxy-4-[4-(Hydroxyldiphenyl- Methyl)-1-Piperidinyl]Butyl] Benzeneacetic Acid Metal Complexes of Biological Interest

Saeed M Arayne1*, Najma Sultana2, Hina Shehnaz3 and Amir Haider4
1Department of Chemistry, University of Karachi, Karachi, Pakistan
2Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
3Department of Environmental Science, Sind Madressatul Islam University, Karachi, Pakistan
4Arysta Life Science Pakistan, Horizon Vista - 3rd Floor, Commercial 10, Block 4, Clifton, Karachi-75600, Pakistan
Corresponding Author : Saeed M Arayne
Department of Chemistry, University of Karachi
Karachi-75270, Pakistan
Tel: +923-332-101-255
E-mail: [email protected]
Received April 23, 2014; Accepted May 28, 2014; Published June 02, 2014
Citation: Arayne SM, Sultana N, Shehnaz H, Haider A (2014) Synthesis and Characterization of α,α-Dimethyl-4-[1-Hydroxy-4-[4-(Hydroxyldiphenyl- Methyl)-1-Piperidinyl]Butyl] Benzeneacetic Acid Metal Complexes of Biological Interest. Mod Chem appl 2:127. doi: 10.4172/2329-6798.1000127
Copyright: © 2014 Arayne SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzene acetic acid generically known as fexofenadine or carboxyterfenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. Metal complexes of fexofenadine with various essential and trace elements of biological interest, have been synthesized and characterized by FT-IR, 1H-NMR, UV, CHN elemental analysis. Conductometric titration was carried out to determine the mole ratio of interaction of the drug and metal. Spectral data clearly showed the complexation of fexofenadine with nitrogen of the piperidine ring in case of magnesium, calcium, chromium and manganese complexes while oxygen of carboxylato group is involved in complexation with iron, cobalt nickel, copper, zinc and cadmium. Elemental analysis reveals monodentate character of these complexes.

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