Synthesis and Characterization of Some New Thiazolidinedione Derivatives Containing a Coumarin Moiety for their Antibacterial and Antifungal ActivitiesEdris Valadbeigi* and Shahram Ghodsi
Department of Chemistry, Faculty of Sciences, Islamic Azad University, Karaj Branch, Karaj, Iran
- *Corresponding Author:
- Edris Valadbeigi
Department of Chemistry, Faculty of Sciences
Islamic Azad University, Karaj Branch, Karaj, Iran
E-mail: [email protected]
Received date: May 26, 2017; Accepted date: May 27, 2017; Published date: June 03, 2017
Citation: Valadbeigi E, Ghodsi S (2017) Synthesis and Characterization of Some New Thiazolidinedione Derivatives Containing a Coumarin Moiety for their Antibacterial and Antifungal Activities. Med Chem (Los Angeles) 7:178-185. doi:10.4172/2161-0444.1000453
Copyright: © 2017 Valadbeigi E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Simple coumarins and analogues are large class of compounds that have attracted their interest for a long time due to their biological activities. They have shown to be useful as anti-tumoural, anti-HIV agents and as CNS active compounds. Furthermore, they have been reported to have multiple biological activities (anti-coagulant, anti-inflammatory), although all these properties have not been evaluated systematically. In addition, their enzyme inhibition properties, antimicrobial and antioxidant activities are other foremost topics in this field of research. A new series of thiazolidinedione derivatives were synthesized by reacting with coumarin moiety and studied for their antibacterial and antifungal activities. The synthesis of compounds (6a-9c) was achieved through the versatile and efficient synthetic route that involved reaction of thiazolidinedione with appropriately α-bromo ketone or α-bromo oxime derivatives (2a, 5c). The structures of these compounds were established by means of IR, 1H-NMR, 13C-NMR Mass and elemental analysis.