alexa Synthesis and Cytotoxic Distinction of Benzo[h]naphtho[
ISSN: 2161-0444

Medicinal chemistry
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Research Article

Synthesis and Cytotoxic Distinction of Benzo[h]naphtho[1,2-b] [1,6] Naphthyridine and its Isomeric Benzo[b]naphtho[1,2-h][1,6] Naphthyridines

Kolandaivel Prabha and K J Rajendra Prasad*

Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India

*Corresponding Author:
K. J. Rajendra Prasad
Department of Chemistry
Bharathiar University
Coimbatore, Tamil Nadu, India
Tel: +919865972521
E-mail: [email protected]

Received date: December 20, 2015; Accepted date: January 25, 2016; Published date: January 27, 2016

Citation: Prabha K, Prasad KJR (2016) Synthesis and Cytotoxic Distinction of Benzo[h]naphtho[1,2-b][1,6] Naphthyridine and its Isomeric Benzo[b]naphtho[1,2-h] [1,6] Naphthyridines. Med chem 6:062-071. doi:10.4172/2161-0444.1000326

Copyright: © 2016 Prabha K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Benzo[h]naphtho[1,2-b][1,6]naphthyridine and its isomeric benzo[b]naphtho[1,2-h][1,6]naphthyridine with aliphatic, aromatic and hetero substitution were synthesized and screened for its antiproliferative activity against four human cancer cell lines. Among these, HeLa cells are more susceptible to compounds 3a, 3b, 9a and 9b with IC50 values of 3.62, 1.05, 6.21 and 1.41 μM respectively. Interestingly chloro substituted compound 9b showed IC50 values of 5.93, 7.01, and 6.81 μM against MCF7, K562 and Hep-G2 cancer cells, which is more active than the standard adriamycin. Furthermore chloro substituted compound 3b displayed good activity against MCF7 (IC50 6.63 μM) and K562 (IC50 7.23 μM) cancer cell lines. This study also revealed that, benzo[h]naphtho[1,2-b][1,6] naphthyridine series were more active than its isomeric benzo[b]naphtho[1,2-h][1,6] naphthyridines.

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