alexa Synthesis and Evaluation of 5-Chloro-2-Methoxy-N-(4-Sulphamoylphenyl) Benzamide Derivatives as Anti-cancer Agents | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Synthesis and Evaluation of 5-Chloro-2-Methoxy-N-(4-Sulphamoylphenyl) Benzamide Derivatives as Anti-cancer Agents

Ahmed M Abdelaziz1,2, MingfengYu1, Peng Li1, Longjin Zhong1, Abdel Nasser B Singab3, Atef G Hanna2, Khaled A Abouzid3, Maged KG Mekhael2 and Shudong Wang1*

1Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia,Adelaide, South Australia 5001, Australia

2Department of Chemistry of Natural Compounds, National Research Centre, Dokki, 12311, Cairo, Egypt

3Faculty of Pharmacy, Ain Shams University, Abbasia, 11566, Cairo, Egypt

*Corresponding Author:
Shudong Wang
Centre for Drug Discovery andDevelopment
Sansom Institute for Health Research
and School of Pharmacy and Medical Sciences
University of South Australia, Adelaide
South Australia 5001, Australia
Tel: +61 8 8302 2372
Fax: +61 8 8302 1087
E-mail: [email protected]

Received May 25, 2015; Accepted June 13, 2015; Published June 15, 2015

Citation: Abdelaziz AM, Yu M, Li P, Zhong L, Singab ANB, et al. (2015) Synthesis and Evaluation of 5-Chloro-2-Methoxy-N-(4-Sulphamoylphenyl) Benzamide Derivatives as Anti-cancer Agents. Med chem 5:253-260. doi: doi:10.4172/2161- 0444.1000272

Copyright: © 2015 Abdelaziz AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Sulphonamides embrace a sublime class of drugs with various biological activities. Since the discovery of E7010 in 1992, several sulphonamides as anti-cancer drug candidates have been identified. Herein, a new series of 5-chloro- 2-methoxy-N-(4-sulphamoylphenyl)benzamide derivatives was synthesised, and their anti-proliferative activity was evaluated against human ovarian cancer (A2780) and colon cancer (HCT-116) cell lines. As one of the most potent antiproliferative agents, compound 4j was further tested against a panel of cancer cell lines revealing that human pancreatic carcinoma (MIA PaCa-2) displayed the highest sensitivity. Cellular mechanistic studies on MIA PaCa-2 cells showed that 4j arrested the G2/M cell cycle and induced apoptosis.

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