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Synthesis and <em>In Vitro</em> Antiproliferative Evaluation of Some B-norcholesteryl thiazole Derivatives | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Synthesis and In Vitro Antiproliferative Evaluation of Some B-norcholesteryl thiazole Derivatives

Yanmin Huang1, Binbin Qi1, Jianguo Cui1,2*, Zhipin Liu1, Chunfang Gan1, Dandan Zhao1, Qifu Lin2 and Haixin Shi2*

1College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning, China

2Guangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resoure Effective Utilization, Qizhou University, China

*Corresponding Author:
Jianguo Cui
Guangxi Colleges
University Key Laboratory of Beibu Gulf Oil
Natural Gas Resoure Effective Utilization
Qizhou University, China
E-mail: [email protected]/[email protected]

Haixin Shi
Guangxi Colleges
University Key Laboratory of Beibu Gulf Oil
Natural Gas Resoure Effective Utilization
Qizhou University, China
E-mail: [email protected]/[email protected]

Received date: July 21, 2015; Accepted date: August 15, 2015; Published date: August 20, 2015

Citation: Huang Y, Qi B, Cui J, Liu Z, Gan C, et al. (2015) Synthesis and In Vitro Antiproliferative Evaluation of Some B-norcholesteryl thiazole Derivatives. Med chem 5:405-411. doi: 10.4172/2161-0444.1000292

Copyright: © 2015 Huang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Some novel B-norcholesteryl thiazole derivatives were synthesized and their structures were characterized by IR, NMR and HRMS. The antiproliferative activity of the compounds against human cervical carcinoma(HeLa), human lung carcinoma (A549), human liver carcinoma (HEPG2) and normal kidney epithelial (HEK293T) cells was assayed. The results revealed that compounds 14 and 17 with a structure of N-methylthiazole showed distinct antiproliferative activity against A549 and HEPG2 cells. Compounds 20-24 with a structure of N-phenylthiazole displayed a selective antiproliferativeactivity on HeLa cells and were almost inactive to normal kidney epithelial cells (HEK293T). The research provided a theoretical reference for the exploration of new anti-cancer agents and may be useful for the design of novel chemotherapeutic drugs.

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