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Synthesis and Pharmacological Evaluation of Some Pyrazoles, Thiazolopyrimidine, Triazolopyrimidine, Pyridone and 2-Iminochromene Containing Naproxenoyl Moiety as NSAIDs
Some novel pyrazoles, thiazolopyrimidine, triazolopyrimidine derivatives containing naproxenoyl moiety were synthesized from the reaction of enaminone derivative 2 with some hydrazines and aminoheterocyclic compounds. Also, some thiazoles were obtained via condensation of acetyl derivative 1 with thiosemicarbazide followed by in situheterocyclization with α-halogenated reagents. Most of the target compounds were then evaluated for their animal toxicity, analgesic and anti-inflammatory activities as NSAIDs.