alexa Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues | OMICS International | Abstract
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Medicinal Chemistry
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Research Article

Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues

Mohamed Jawed Ahsan1*, Vikram Pratap Singh Rathod1, Monika Singh1, Ramdayal Sharma1, Surender Singh Jadav2, Sabina Yasmin2, Salahuddin3 and Pradeep Kumar1

1Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan 302 023, India

2Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835 215, India

3Department of Pharmaceutical Technology, Noida Institute of Engineering and Technology, Knowledge Park II, Greater Noida, Uttar Pradesh 201 306, India

*Corresponding Author:
Mohamed Jawed Ahsan
Department of Pharmaceutical Chemistry
Maharishi Arvind College of Pharmacy
Jaipur, Rajasthan 302 023, India
Tel: +91 9694087786
Fax: +91 144 5121120
E-mail: [email protected]

Received date: November 19, 2013; Accepted date: December 19, 2013; Published date: December 21, 2013

Citation: Ahsan MJ, Singh Rathod VP, Singh M, Sharma R, Jadav SS, et al. (2013) Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5- aryl-1,3,4-Oxadiazole Analogues. Med chem 3:294-297. doi:10.4172/2161- 0444.1000154

Copyright: © 2013 Ahsan MJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Among a series of ten, 2-(4-chlorophrnyl)-5-aryl-1,3,4-oxadiazole analogs, 4c showed maximum activity on various cancer cell lines, with average growth percent of 95.37%. The molecular docking studies for the compounds 4a & 4c showed that the residue Cys797 is present near to the para substitution of phenyl group while the five member oxadiazole ring of ligandswas lying near to Leu792 and Met 793 of EGFR tyrosine kinase active

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