alexa Synthesis, Antimicrobial and Antioxidant Evaluation of
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Synthesis, Antimicrobial and Antioxidant Evaluation of Novel 5, 6-dihydro- 3-(substituted phenyl)[1,3,4]thiadiazine-7-one Derivatives

Prabhakar Kumar Verma*

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

*Corresponding Author:
Prabhakar Kumar Verma
Department of Pharmaceutical Sciences
Maharshi Dayanand University
Rohtak-124 001, Haryana, India
Tel: 9992581437
E-mail: [email protected]

Received Date: May 04, 2017 Accepted Date: May 16, 2017 Published Date: May 20, 2017

Citation: Verma PK (2017) Synthesis, Antimicrobial and Antioxidant Evaluation of Novel 5, 6-dihydro-3-(substituted phenyl) [1,3,4] thiadiazine-7-one Derivatives. Med Chem (Los Angeles) 7: 880-883. doi: 10.4172/2161-0444.1000446

Copyright: © 2017 Verma PK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A series of 1, 2, 4-triazole derivatives (1-17, Scheme 1) was synthesized and evaluated for their antimicrobial and antioxidant potential. Results of antimicrobial screening of the synthesized compounds indicated that most of the synthesized compounds showed good activity as compare to the norfloxacin as antibacterial and fluconazole as antifungal standard drugs. Compounds 7 and 12 were found to be most effective against various strains used for the antimicrobial activity like S. aureus, B. subtilis, E. coli, Candida albicans and A. niger using tube dilution method having MIC 3.12 μg/ml for S. aureus and 06.25 μg/ml for rest strains. All the synthesized compounds also evaluated for antioxidant activity by DPPH method and results revealed that the compounds 8 and 16 showed antioxidant activity comparable to the positive control ascorbic acid.


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