Synthesis, Antioxidant and Cytotoxic Activities of Novel Naphthoquinone Derivatives from 2,3-Dihydro-2,3-Epoxy-1,4- Naphthoquinone
Berghot MA, Kandeel EM, Abdel-Rahman AH and Marwa Abdel-Motaal*
Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, 35516, Egypt
- *Corresponding Author:
- Marwa Abdel-Motaal
Department of Chemistry, Faculty of Science
Mansoura University, El-Gomhoria Street, Mansoura, 35516, Egypt
Tel: +20168059390, +20502223852
E-mail: [email protected]
Received date: January 19, 2014; Accepted date: March 22, 2014; Published date: March 25, 2014
Citation: Berghot MA, Kandeel EM, Abdel-Rahman AH, Abdel-Motaal M (2014) Synthesis, Antioxidant and Cytotoxic Activities of Novel Naphthoquinone Derivatives from 2,3-Dihydro-2,3-Epoxy-1,4- Naphthoquinone. Med chem 4:382-389. doi:10.4172/2161-0444.1000169
Copyright: © 2014 Berghot MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A series of newly naphthoquinone derivatives were synthesized using 2,3- dihydro-2,3-epoxy-1,4-naphthoquinone (1) as a starting material. The corresponding acetophenyl derivative 7 was used as building blocks for synthesis of different heterocycles incorporated naphthoquinone moiety. The newly synthesized compounds were characterized utilizing the corresponding analytical and spectroscopic data and evaluated as antioxidant activity by superoxide (NBT) free radical scavenging methods. Compounds 21, 22 promosing the more potent antioxidant agents than ascorbic acid. Moreover, the newly synthesized quinones were tested for their Cytotoxicity by brine shrimp lethality bioassay. Quinone derivatives 3, 12, 18, 23 were proven to be the best potent cytotoxic agents.