alexa Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents
ISSN: 2161-0401

Organic Chemistry: Current Research
Open Access

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Research Article

Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents

Abdel-Sattar S. Hamad Elgazwy1*, Ekhlass Nassar2 and Myssoune Y. Zaki3
1Department of Chemistry Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
2Chemistry Department, Faculty of Women’s for Arts, Science and Education, Ain Shams University, Heleopolis, Cairo, Egypt
3National Organization for Drug Control & Research, P.O. Box: 29 Cairo, Egypt
Corresponding Author : Abdel-Sattar S. Hamad Elgazwy
Department of Chemistry Faculty of Science
Ain Shams University
Abbassia 11566, Cairo, Egypt
E-mail:
[email protected]
Received November 13, 2012; Accepted November 22, 2012; Published November 26, 2012
Citation: Hamad Elgazwy AS, Nassar E, Zaki MY (2012) Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents. Organic Chem Curr Res 1:112. doi:10.4172/2161-0401.1000112
Copyright: © 2012 Hamad Elgazwy AS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present article describes the synthesis of two novel series of 5-(benzofuran-2-yl)-3-(4-(piperidin-1-yl)phenyl)-
2,3-dihydropyrazole-1-carbothioamide 6 and 1-(4-(3-(benzofuran-2-yl)-2-(4-arylthiazol-2-yl)-2,5-dihydro-1H-pyrazol-
5-yl)phenyl)piperidine 8a-d. All the newly synthesized target compounds (3, 4, 5, 6 and 8a-d) were screened for
their in vivo anti-inflammatory (AI) activity using carrageenan-induced rat paw edema assay and in vitro antibacterial
activity
against two Gram-positive and two Gram-negative bacteria. All eight compounds (3, 4, 5, 6, and 8a-d) showed
consistently excellent AI activity (≥ 70% inhibition), at 3 and 4 h after the carrageenan injection, comparable to that
of standard drug indomethacin (78%) whereas the remaining twelve compounds have shown significant activity with
57–75% inhibition after 3 h and 56–63% inhibition after 4 h. All the tested compounds showed moderate antibacterial
properties.

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