alexa Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents | OMICS International| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Current Res 2012, Vol 1(5): 112
  • DOI: 10.4172/2161-0401.1000112

Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents

Abdel-Sattar S. Hamad Elgazwy1*, Ekhlass Nassar2 and Myssoune Y. Zaki3
1Department of Chemistry Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
2Chemistry Department, Faculty of Women’s for Arts, Science and Education, Ain Shams University, Heleopolis, Cairo, Egypt
3National Organization for Drug Control & Research, P.O. Box: 29 Cairo, Egypt
*Corresponding Author : Abdel-Sattar S. Hamad Elgazwy, Department of Chemistry Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt, Email: [email protected]

Received Date: Nov 13, 2012 / Accepted Date: Nov 22, 2012 / Published Date: Nov 26, 2012

Abstract

The present article describes the synthesis of two novel series of 5-(benzofuran-2-yl)-3-(4-(piperidin-1-yl)phenyl)- 2,3-dihydropyrazole-1-carbothioamide 6 and 1-(4-(3-(benzofuran-2-yl)-2-(4-arylthiazol-2-yl)-2,5-dihydro-1H-pyrazol- 5-yl)phenyl)piperidine 8a-d. All the newly synthesized target compounds (3, 4, 5, 6 and 8a-d) were screened for their in vivo anti-inflammatory (AI) activity using carrageenan-induced rat paw edema assay and in vitro antibacterial activity against two Gram-positive and two Gram-negative bacteria. All eight compounds (3, 4, 5, 6, and 8a-d) showed consistently excellent AI activity (≥ 70% inhibition), at 3 and 4 h after the carrageenan injection, comparable to that of standard drug indomethacin (78%) whereas the remaining twelve compounds have shown significant activity with 57–75% inhibition after 3 h and 56–63% inhibition after 4 h. All the tested compounds showed moderate antibacterial properties.

Keywords: 2,3-dihydropyrazole; Thiazoles; Anti-inflammatory activity; Antibacterial activity

Citation: Hamad Elgazwy AS, Nassar E, Zaki MY (2012) Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents. Organic Chem Curr Res 1: 112. Doi: 10.4172/2161-0401.1000112

Copyright: ©2012 Hamad Elgazwy AS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment
Share This Article
Relevant Topics
Recommended Conferences
  • International Conference on Organic and Inorganic Chemistry

    July 12-13, 2018 Paris, France

  • 5th International Conference on Organic and Inorganic Chemistry

    July 12-13, 2018 Paris, France

  • International Conference on Organic & Inorganic Chemistry

    July 18-19 , 2018 Atlanta, USA

  • International conference on Organic Farming & Biological Treatment

    September 19-20, 2018 Dallas, USA

  • 10th Europian Organic Chemistry Congress

    March 21-22, 2019 Rome, Italy

Viewmore
Article Usage
  • Total views: 12088
  • [From(publication date): 12-2012 - May 25, 2018]
  • Breakdown by view type
  • HTML page views: 8283
  • PDF downloads: 3805
Leave Your Message 24x7