alexa Synthesis, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases Based on 1,3-Docarbonyl Phenyl Dihydrazide, 1,4-Docarbonyl Phenyl Dihydrazide| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Curr Res 2013, Vol 2(3): 122
  • DOI: 10.4172/2161-0401.1000122

Synthesis, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases Based on 1,3-Docarbonyl Phenyl Dihydrazide, 1,4-Docarbonyl Phenyl Dihydrazide

Eissa HH*
Chemistry Department, Applied College Sciences, University of Hajah, Yemen
*Corresponding Author : Eissa HH, Chemistry Department, Applied College Sciences, University of Hajah, Yemen, Tel: +202 3536 9100, Email: [email protected]

Received Date: Oct 10, 2013 / Accepted Date: Dec 11, 2013 / Published Date: Dec 18, 2013

Abstract

Three new Macrocyclic Hydrazone Schiff bases were synthesized by condensation of intermediate compounds: 1,6- bis (2-formylphenyl) hexane and glutaraldehyde with both dihydrazide of isophthalic acid and dihydrazide of terephthalic acid. Identification of these macrocyclic Schiff bases ligands (V, VI, VII). The Schiff bases were checked by different spectral technique (LC-MS, 1H-NMR, IR, elemental analyses). The new Macrocyclic Hydrazone Schiff Bases were studied for antibacterial activities against Gram positive (Bacillus subtilis and Staphylococcus aureus) and Gram negative (Salmonella typhi and Escherichia coli). The compound ligands exhibited a variable activity of inhibition on the growth of the bacteria.

Citation: Eissa HH (2013) Synthesis, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases Based on 1,3-Docarbonyl Phenyl Dihydrazide, 1,4-Docarbonyl Phenyl Dihydrazide. Organic Chem Curr Res 2: 122. Doi: 10.4172/2161-0401.1000122

Copyright: © 2013 Eissa HH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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