alexa Synthesis, Characterization and Antibacterial Activity
ISSN: 2161-0401

Organic Chemistry: Current Research
Open Access

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Research Article

Synthesis, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases Based on 1,3-Docarbonyl Phenyl Dihydrazide, 1,4-Docarbonyl Phenyl Dihydrazide

Eissa HH*
Chemistry Department, Applied College Sciences, University of Hajah, Yemen
Corresponding Author : Eissa HH
Chemistry Department, Applied College Sciences
University of Hajah, Yemen
Tel: +202 3536 9100
E-mail: [email protected]
Received October 10, 2013; Accepted December 11, 2013; Published December 18, 2013
Citation: Eissa HH (2013) Synthesis, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases Based on 1,3-Docarbonyl Phenyl Dihydrazide, 1,4-Docarbonyl Phenyl Dihydrazide. Organic Chem Curr Res 2:122. doi: 10.4172/2161-0401.1000122
Copyright: © 2013 Eissa HH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Three new Macrocyclic Hydrazone Schiff bases were synthesized by condensation of intermediate compounds: 1,6- bis (2-formylphenyl) hexane and glutaraldehyde with both dihydrazide of isophthalic acid and dihydrazide of terephthalic acid. Identification of these macrocyclic Schiff bases ligands (V, VI, VII). The Schiff bases were checked by different spectral technique (LC-MS, 1H-NMR, IR, elemental analyses). The new Macrocyclic Hydrazone Schiff Bases were studied for antibacterial activities against Gram positive (Bacillus subtilis and Staphylococcus aureus) and Gram negative (Salmonella typhi and Escherichia coli). The compound ligands exhibited a variable activity of inhibition on the growth of the bacteria.

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