alexa Synthesis Characterization and Antimicrobial Activities
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Synthesis Characterization and Antimicrobial Activities of Azithromycin Metal Complexes

Saeed Arayne M1*, Najma Sultana2, Sana Shamim2 and Asia Naz2
1Department of Chemistry, University of Karachi, Pakistan
2Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Pakistan
Corresponding Author : Saeed Arayne M
Department of Chemistry, University of Karachi
Karachi-75270, Pakistan
Tel: +923-332-101-255
E-mail: [email protected]
Received April 24, 2014; Accepted September 10, 2014; Published September 15, 2014
Citation: Saeed Arayne M, Sultana N, Shamim S, Naz A (2014) Synthesis Characterization and Antimicrobial Activities of Azithromycin Metal Complexes.Mod Chem appl 2:133. doi: 10.4172/2329-6798.1000133
Copyright: © 2014 Saeed Arayne M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Azithromycin is a well-established antimicrobial agent which has been widely prescribed for the treatment of respiratory tract infections owing to its high efficacy and safety. Various essential metal complexes of azithromycin were synthesized and characterized by techniques as UV, FT-IR, NMR, atomic absorption and elemental analysis. Spectroscopic studies of complexes suggested that the –N(CH3)2 and hydroxyl group of desosamine sugar moiety present in azithromycin has been involved in complexation i.e., azithromycin ligand (L) behaves bidentately for complexation with different metal ions such as Mg (II), Ca (II), Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II) and Cd (II). These complexes were then subjected to in-vitro antibacterial and antifungal studies against several Gram positive, Gram negative bacteria and fungi. ANOVA studies illustrates that all the tested complexes exhibited significantly mild to moderate antibacterial activity against all bacterial strains and highly significant against fungus C. albican.

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