alexa Synthesis Characterization and Antimicrobial Activity o
ISSN: 2161-0401

Organic Chemistry: Current Research
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Research Article

Synthesis Characterization and Antimicrobial Activity of N-nitroso-2, 6-Diphenylpiperidin-4-One Semicarbazone

Mubarak S1, Sirajudheen P2*, Shebin KSM1, Muhasina M1 and Rishana T1
1Asssociate professor, Jamal Mohammed College, Trichy, Tamil Nadu, India-620020
2HOD & Assistant Professor, Department of chemistry, WMO Imam Gazzali Arts and science College, Koolivayal, Department of Physical, Environmental, and Computer Science, CUNY-Medgar Evers College, 1636 Bedford Ave, Brooklyn, NY 11225, USA
Corresponding Author : Sirajudheen P
HOD and Assistant Professor
Department of chemistry, WMO Imam Gazzali Arts
and science College, koolivayal, Cherukattoor Post
Wayanad, Kerala, India-670721
Tel: +919961136210
E-mail: [email protected]
Received: May 30, 2015; Accepted: June 08, 2015; Published: June 15, 2015
Citation: Mubarak S, Sirajudheen P, Shebin KSM, Muhasina M, Rishana T (2015) Synthesis Characterization and Antimicrobial Activity of N-nitroso-2, 6-Diphenylpiperidin-4-One Semicarbazone. Organic Chem Curr Res 4:141. doi:10.4172/2161-0401.1000141
Copyright: © 2015 Mubarak S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Among the family of heterocyclic compounds, The nitrogen containing six membered heterocyle, the piperidine structural was the most dominant and very prevalent element in nature and often found to be naturally occurring bioactive compounds such as alkaloids. Piperidin-3-one derivatives are used as precursors for the synthesis of antimalarial agents febrifugine and Isofebrifugine. Piperidin-4-ones mostly display varied and potent biological properties such as antiviral, antitumour, analgesic, antimicrobial, fungicidal, herbicidal, insecticidal, antihistaminic, anti-inflammatory and anticancer. CNS stimulant and recent reports suggest that compounds containing piperidin-4-one moiety elicit excellent activity when aromatic substitutions are present at 2- and/or 6-positions. In this work, the compound N-nitroso-2,6- diphenylpiperidin-4-one semicarbazone has been prepared and analyzed. The product showed positive nitrogen test (Lassign test), a single spot in TLC and sharp melting point for the purity of the compound. The structure of the compound was further confirmed from the CHN analysis FT-IR, and 1H NMR Spectral data and the compound have being screened for its antimicrobial activity against gram positive bacteria Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria Escherichia coli by using ciprofloxacin as standard and fungi Candida albicans by using cetramazole as standard. The compound exhibited significant activities against all the tested bacterial and fungal strains.

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