Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex
Nitin Kumar Sharma, Rakesh Kumar Ameta and Man Singh*
School of Chemical Sciences, Central University of Gujarat, Gandhinagar- 382030, India
- *Corresponding Author:
- Man Singh
School of Chemical Sciences
Central University of Gujarat
Gandhinagar- 382030, India
E-mail: [email protected]
Received date: September 29, 2015; Accepted date: November 20, 2015; Published date: November 30, 2015
Citation: Sharma NK, Ameta RK, Singh M (2015) Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex. Cancer Med Anticancer Drug 1:101. doi:10.4172/cmacd.1000101
Copyright: © 2015 Sharma NK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A benzylamine supported palladium (II) complex has been synthesized and characterized using different spectroscopic techniques, such as FTIR, UV/Vis., 1H, 13C NMR and LCMS. The semi crystalline nature of the complex was investigated through powder XRD and SAED pattern analysed by HRTEM. The in vitro biological study against breast cancer cell lines MCF-7 and MDA-MB-231 was not much effective but their strong DNA binding activity (DBA) compared to free ligand suggested them as a good DNA binder and makes them interesting against other cancerous cell lines. The DBA further supported by physicochemical studies such as surface tension and viscosity of complex+DNA which inferred the disruption and intercalation of DNA and complex. The scavenging activity (SA) also proves the anticancer nature of complex, in this context, the scavenging activity of complex was determined through DPPH• free radical and the result indicates good antioxidant behaviour of complexes.