alexa Synthesis, Characterization of Substituted (4-Oxo-3-Phe
ISSN: 2150-3494

Chemical Sciences Journal
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Synthesis, Characterization of Substituted (4-Oxo-3-Phenyl-3,4-Dihydro Quinazolin-2-yl)Methyl Nitrite Derivatives and Evaluation of their Antimicrobial Activity

Chaitanya P1, Guguloth R2*, Damodhar S1 and Ravinder AN1

1University College of Technology, Osmania University, Hyderabad, Telangana, India

2Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India

*Corresponding Author:
Guguloth R
Department of Chemistry
University College of Science
Osmania University, Hyderabad, Telangana, India
Tel: 9486745607
E-mail: [email protected]

Received date: May 02, 2017; Accepted date: May 23, 2017; Published date: June 09, 2017

Citation: Chaitanya P, Guguloth R, Damodhar S, Ravinder AN (2017) Synthesis, Characterization of Substituted (4-Oxo-3-Phenyl-3,4-Dihydro Quinazolin-2-yl) Methyl Nitrite Derivatives and Evaluation of their Antimicrobial Activity. Chem Sci J 8:157. doi: 10.4172/2150-3494.1000157

Copyright: © 2017 Chaitanya P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Synthesis of substituted (4-oxo-3-phenyl-3,4-dihydro quinazolin-2-yl)methyl nitrite derivatives[5(a-j)] have been prepared oxidation reaction of 6-chloro-2-(chloromethyl)-3-[phenyl] quinazolin-4(3H)-one(4) with AgNO3. Compound (5) prepared from starting meterial are 5-chloro-2-[(chloroacetyl)amino]benzoic acid (1) is undergoes to cyclization with acetic anhydride to form 5-chloro-2-[(chloroacetyl)amino]benzoic acid (2) in yield 72%. 5-chloro-2-[(chloroacetyl) amino]benzoic acid(2) undergoes ro cyclisation with acetic anhydride under reflux conidition to form 6-chloro- 2-(chloromethyl)-4H-3,1-benzoxazin-4-one (3) now this compound have been reacted with glycial acetic acid in presence of aniline to form 6-chloro-2-(chloromethyl)-3-[phenyl] quinazolin-4(3H)-one(4). Chareterization done by 1H-NMR, 13C-NMR, IR, MASS spectral analysis. Evaluation of antibacterial activity by Gram-positive bacteria viz. Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus and three Gram-negative bacteria viz. Pseudomonas aeruginosa, Klebsiella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigates, Trichophyton rubrum and Trichophyton mentagrophytes. Most of the compounds are exihibits more potential activity.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version