alexa Synthesis, DNA-binding, Photocleavage and in vitro Cyto
ISSN: 2161-0444

Medicinal chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Synthesis, DNA-binding, Photocleavage and in vitro Cytotoxicity of Novel Imidazole[4,5-f][1,10]phenanthroline-based Oxovanadium Complexes

Peng Ying1, Xuyan Tian2, Pengfei Zeng1, Jiazheng Lu1*, Hongyuan Chen2* and Manshan Xiao2

1Department of Chemistry, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P.R. China

2Department of Pathogen Biology and Immunology, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510060, P.R. China

*Corresponding Author:
Jiazheng Lu
Department of Chemistry, School of Pharmacy
Guangdong Pharmaceutical University
Guangzhou, 510006, P.R. China
Tel: +86-20-39352122
Fax: +86-20-39352129
E-mail: [email protected]

Hongyuan Chen
Department of Pathogen Biology and Immunology
School of Basic Course, Guangdong Pharmaceutical University
Guangzhou 510060, P.R. China
Tel: 86-020-3935219
E-mail: [email protected]

Received date: June 28, 2014; Accepted date: July 28, 2014; Published date: July 31, 2014

Citation: Ying P, Tian X, Zeng P, Lu J, Chen H, et al. (2014) Synthesis, DNAbinding, Photocleavage and in vitro Cytotoxicity of Novel Imidazole[4,5-f] [1,10]phenanthroline-based Oxovanadium Complexes. Med chem 4:549-557. doi:10.4172/2161-0444.1000193

Copyright: © 2014 Ying P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Three novel imidazole[4,5-f][1,10]phenanthroline-based oxovanadium complexes [VO(hntdtsc)(HPIP)] (1) (hntdtsc = 2-hydroxyl-1-naphthaldehyde thiosemicarbazone, HPIP = 2-(2-hydroxylphenyl)imidazole[4,5-f][1,10]phenanthroline), [VO(hntdtsc)(m-HPIP)] (2) (m-HPIP = 2-(3-hydroxylphenyl)imidazole[4,5-f][1,10]phenanthroline), [VO(hntdtsc)(p-HPIP) (3) (p-HPIP = 2-(4-hydroxylphenyl)imidazole[4,5-f][1,10]phenanthroline), have been synthesized and characterized by elemental analyses and spectroscopic techniques. Their DNA-binding properties with calf-thymus DNA (CT-DNA) were studied by various methods. The cytotoxicity of these three complexes was evaluated by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The electronic spectral results reveal that three complexes can bind to CT-DNA by intercalation mode. The electrophoresis studies also show that they can efficiently cleave pBR322 DNA. The in vitro antiproliferative activity of complex 1 against human CaSki, SiHa, K562, HepG2, EC9706 and EC109 cell lines is proved to be more effective than both 2 and 3.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords