alexa Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents

Srinuvasarao Rayavarapu1, Sunanda Kumari Kadiri2, Mahaboob Basha Gajula1, Mangarao Nakka1, Ramu Tadikonda1, Nagendra Sastry Yarla1 and Siddaiah Vidavalur1*

1Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam, India

2Department of Microbiology, Andhra University, Visakhapatnam, India

3Department of Biotechnology, Gitam University, Visakhapatnam, India

*Corresponding Author:
Siddaiah Vidavalur
Department of Organic Chemistry & FDW
Andhra University, Visakhapatnam-530003, India
Tel: 09440754164
E-mail: [email protected]

Received date: February 14, 2014; Accepted date: March 22, 2014; Published date: March 24, 2014

Citation: Rayavarapu S, Kadiri SK, Gajula MB, Nakka M, Tadikonda R, et al. (2014) Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents. Med chem 4:367-372. doi:10.4172/2161-0444.1000167

Copyright: © 2014 Rayavarapu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A new naturally occurring N1, N6-dihydrocinnamyl putrescine bisamide, JBIR-94, along with nine structural analogs and a series of substituted phenyl and alkyl putrescine bisamides have been synthesized from putrescine and appropriately substituted carboxylic acids, through carboxylic acid chlorides. Antimicrobial, 5-Lipooxygenase enzyme inhibitory and antioxidant studies were performed for all synthesized compounds. Dihydrocinnamyl series of putrescine bisamides (4a-4i) showed good bioactivities compared to substituted phenyl (6a-6g) and diakyl (6h-6j) series of compounds. Among all compounds, 4h (methylenedioxy analog) and 4a (JBIR-94) showed good antimicrobial, antiinflammatoryand antioxidant activities.

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