alexa Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents

Srinuvasarao Rayavarapu1, Sunanda Kumari Kadiri2, Mahaboob Basha Gajula1, Mangarao Nakka1, Ramu Tadikonda1, Nagendra Sastry Yarla1 and Siddaiah Vidavalur1*

1Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam, India

2Department of Microbiology, Andhra University, Visakhapatnam, India

3Department of Biotechnology, Gitam University, Visakhapatnam, India

*Corresponding Author:
Siddaiah Vidavalur
Department of Organic Chemistry & FDW
Andhra University, Visakhapatnam-530003, India
Tel: 09440754164
E-mail: [email protected]

Received date: February 14, 2014; Accepted date: March 22, 2014; Published date: March 24, 2014

Citation: Rayavarapu S, Kadiri SK, Gajula MB, Nakka M, Tadikonda R, et al. (2014) Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents. Med chem 4:367-372. doi:10.4172/2161-0444.1000167

Copyright: © 2014 Rayavarapu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A new naturally occurring N1, N6-dihydrocinnamyl putrescine bisamide, JBIR-94, along with nine structural analogs and a series of substituted phenyl and alkyl putrescine bisamides have been synthesized from putrescine and appropriately substituted carboxylic acids, through carboxylic acid chlorides. Antimicrobial, 5-Lipooxygenase enzyme inhibitory and antioxidant studies were performed for all synthesized compounds. Dihydrocinnamyl series of putrescine bisamides (4a-4i) showed good bioactivities compared to substituted phenyl (6a-6g) and diakyl (6h-6j) series of compounds. Among all compounds, 4h (methylenedioxy analog) and 4a (JBIR-94) showed good antimicrobial, antiinflammatoryand antioxidant activities.

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