Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents
- *Corresponding Author:
- Siddaiah Vidavalur
Department of Organic Chemistry & FDW
Andhra University, Visakhapatnam-530003, India
E-mail: [email protected]
Received date: February 14, 2014; Accepted date: March 22, 2014; Published date: March 24, 2014
Citation: Rayavarapu S, Kadiri SK, Gajula MB, Nakka M, Tadikonda R, et al. (2014) Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents. Med chem 4:367-372. doi:10.4172/2161-0444.1000167
Copyright: © 2014 Rayavarapu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A new naturally occurring N1, N6-dihydrocinnamyl putrescine bisamide, JBIR-94, along with nine structural analogs and a series of substituted phenyl and alkyl putrescine bisamides have been synthesized from putrescine and appropriately substituted carboxylic acids, through carboxylic acid chlorides. Antimicrobial, 5-Lipooxygenase enzyme inhibitory and antioxidant studies were performed for all synthesized compounds. Dihydrocinnamyl series of putrescine bisamides (4a-4i) showed good bioactivities compared to substituted phenyl (6a-6g) and diakyl (6h-6j) series of compounds. Among all compounds, 4h (methylenedioxy analog) and 4a (JBIR-94) showed good antimicrobial, antiinflammatoryand antioxidant activities.