alexa Synthesis of Some Novel Fused Heterocyclic Compounds Derivatives from Bis-chalcones | OMICS International| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Curr Res,
  • DOI: 10.4172/2161-0401.1000159

Synthesis of Some Novel Fused Heterocyclic Compounds Derivatives from Bis-chalcones

Amira A Ghoneim1,2* and Ahmed F El-Farargy2
1Chemistry Department, College of Science, Al Jouf University, Sakaka, Kingdom of Saudi Arabia
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, EG-44519, Egypt
*Corresponding Author : Amira A Ghoneim, Chemistry Department, Faculty of Science, Zagazig University, Zagazig, EG-44519, Egypt, Tel: 01012425368, Email: [email protected]

Received Date: Sep 09, 2015 / Accepted Date: Jan 19, 2016 / Published Date: Jan 26, 2016

Abstract

A chalcone was prepared by the reaction of 1,4-diacetylbenzene with benzaldehyde. Reaction of this chalcone with cynanothioacetamide/guanidine hydrochloride and malnonitrile in presence of piperdene afforded the corresponding pyridine, pyrimidine, and pyrans derivatives in good yields respectively. Further, bis-chalcone 1 was cyclized to pyrazole analogs by using thiosemicarbazide, semicarbazide and tertiarybutylcarbazate. The newly heterocyclic compounds have been characterized by IR, 1H-NMR and elemental analyses.

Keywords: 1,4-Diacetylbenzene; Tertiarybutylcarbazate; Cynanothioacetamide

Citation: Ghoneim AA, El-Farargy AF (2016) Synthesis of Some Novel Fused Heterocyclic Compounds Derivatives from Bis-chalcones. Organic Chem Curr Res 5: 159. Doi: 10.4172/2161-0401.1000159

Copyright: © 2016 Ghoneim AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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