alexa Synthesis, Pharmacological Evaluation and In-Silico Studies of Some Piperidine Derivatives as Potent Analgesic Agents | OMICS International | Abstract
ISSN: 2329-6631

Journal of Developing Drugs
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Research Article

Synthesis, Pharmacological Evaluation and In-Silico Studies of Some Piperidine Derivatives as Potent Analgesic Agents

Sumaira Ansari1*, Nousheen Mushtaq1, Sadia Arif1, Ahsaan Ahmed1,2, Shamim Akhtar1, Rabya Munawar1, Huma Naseem1, Sadia Meer1, Zafar Saied Saify3, Muhammad Arif1 and Qurratul-ain Leghari1,4

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

2Jinnah Sindh Medical University, Institute of Pharmaceutical Sciences, Karachi, Pakistan

3International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan

4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ziauddin University Clifton, Karachi, Pakistan

*Corresponding Author:
Ansari S
Department of Pharmaceutical Chemistry
Faculty of Pharmacy
University of Karachi, Pakistan
Tel: +92 345 3284865
E-mail: [email protected]

Received Date: March 13, 2017 Accepted Date: March 22, 2017 Published Date: March 24, 2017

Citation: Ansari S, Mushtaq N, Arifa S, Ahmed A, Akhtar S, et al. (2017) Synthesis, Pharmacological Evaluation and In-Silico Studies of Some Piperidine Derivatives as Potent Analgesic Agents. J Dev Drugs 6: 170. doi:10.4172/2329-6631.1000170

Copyright: ©2017 Ansari S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In present study, some 4-piperidinopiperidine (PP) and 4-amino methylpiperidine (AMP) derivatives (PP1-3 and AMP4-9) have been synthesized to explore their analgesic potential. Activity of compounds evaluated by in-vivo thermal (tail immersion) method produced significant analgesia at different doses. Docking results explained good binding affinity of synthesized derivatives and potential interaction of all compounds with mu-opioid receptor. The pharmacophoric model of synthesized compounds showed possible structural features required for analgesic activity when compared with standards (Fentanyl, Morphine, Pethidine). Among all PP1, AMP5 and AMP6 emerged out as potent analgesic agents.

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