Synthesis, Spectroscopic and Biologically Assessments of Calcium(II), Zinc(II), Palladium(II) and Gold(III) Sulfacetamide Sodium Complexes: Gold(III) Nano Medical Complex as an Anticancer Agent
- *Corresponding Author:
- Fatima AI Al-Khodir
Department of Chemistry, College of Science
Princess Nora Bint Abdul Rahman University
E-mail: [email protected]
Received Date: August 28, 2015 Accepted Date: September 05, 2015 Published Date: October 01, 2015
Citation: Al-Khodir FAI (2015) Synthesis, Spectroscopic and Biologically Assessments of Calcium(II), Zinc(II), Palladium(II) and Gold(III) Sulfacetamide Sodium Complexes: Gold(III) Nano Medical Complex as an Anticancer Agent. J Nanomed Nanotechnol 6:326. doi:10.4172/2157-7439.1000326
Copyright: © 2015 Al-Khodir FAI. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The preparation of metal-sulfa drug complexes has an important topic due to their biological applications as chemotherapeutic agents against bacterial infections in microorganism. This paper report the synthesis, characterization and antimicrobial screening of synthesized Ca(II), Zn(II), Pd(II) and Au(II) sulfacetamide sodium (SAM-Na) drug complexes. These complexes were assigned based on elemental analyses, molar conductance and some of essential spectral techniques like IR, 1H-NMR, and electronic spectroscopy. These analyses prove that the sulfacetamide sodium salt was reacted with Ca(II), Zn(II) and Pd(II) metal ions as a bidentate ligand through both oxygen atoms of acetamide and sulfonyl groups. On contrary, the SAM-Na acts as a monodentate ligand through its –NH2 amino in case of gold(III) complex. These complexes were placed in the following formulas: [Ca(SAM-Na)(Cl)2)].5H2O (1), [Zn(SAMNa)( Cl)2].3H2O (2), [Pd(SAM-Na)(Cl)2]. 3H2O (3) and [Au(SAM-Na)(Cl)3].4H2O (4). The molar conductance data reveals that all SAM-Na complexes is non-electrolyte. The morphological structures of SAM-Na complexes were checked using X-ray powder diffraction (XRD) and scanning electron microscope (SEM) analyzer.