Synthesis, Structural Elucidation and Anti-Bacterial Evaluation of Some Novel Heterocyclic Molecules Derived from Thieno [2,3-d] Pyrimidine as a Core UnitVirupakshi Prabhakar1*, Sangu Jagadish Babu2, Sangu VN Lalitha Siva Jyothi1, Sangu VN Lahari2 and Venkateswarlu Bandi3
- *Corresponding Author:
- Prabhakar V
Faculty of Engineering Chemistry, SVR Engineering College
Jawaharlal Nehru Technological University - Anantapuramu (JNTU-A)
Nandyal-518 501, Kurnool, Andhra Pradesh, India
E-mail: [email protected]
Received Date: October 14, 2016; Accepted Date: October 29, 2016; Published Date: November 15, 2016
Citation: Prabhakar V, Babu SJ, Sangu VN LS Jyothi, Lahari SVN, et al. (2016) Synthesis, Structural Elucidation and Anti-Bacterial Evaluation of Some Novel Heterocyclic Molecules Derived from Thieno [2,3-d] Pyrimidine as a Core Unit. Organic Chem Curr Res 5:172. doi: 10.4172/2161-0401.1000172
Copyright: © 2016 Prabhakar V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A series of novel 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2-substituted phenyl/Heterocyclic Thieno[2,3-d] Pyrimidine (8 a-j) derivatives were synthesized by a facile Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Bacillus subtilis and Staphylocouccus aureus from Gram positive group of bacteria and Escherichia coli and Klebsiella pneumonia from Gram negative group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin and Ketoconazole. From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8i, 8h, 8e and 8j possess good activity.