alexa Synthetic Peptides of Epstein-Barr Virus-major Envelope Glycoprotein-350/220 do not Prevent Infection in a Rabbit Epstein-Barr Virus Infection Model
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

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Research Article

Synthetic Peptides of Epstein-Barr Virus-major Envelope Glycoprotein-350/220 do not Prevent Infection in a Rabbit Epstein-Barr Virus Infection Model

Kaoru Kato1*, Hitoshi Sano1, Keiko Nagata1, Hirotsugu Sugihara1, Kyosuke Kanai2, Satoshi Kuwamoto1, Masako Kato1, Ichiro Murakami1 and Kazuhiko Hayashi1

1Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Japan

2Department of Virology I, National Institute of Infectious Disease, Tokyo, Japan

*Corresponding Author:
Kaoru Kato
Division of Molecular Pathology, Department of Pathology
Faculty of Medicine, Tottori University
Yonago, Tottori, 683-8503, Japan
Tel: (+81) 859-38-6063
Fax: (+81) 859-38-6060
E-mail: [email protected]

Received date: July 23, 2012; Accepted date: September 27, 2012; Published date: October 03, 2012

Citation: Kato K, Sano H, Nagata K, Sugihara H, Kanai K, et al. (2012) Synthetic Peptides of Epstein–Barr Virus-major Envelope Glycoprotein-350/220 do not Prevent Infection in a Rabbit Epstein–Barr Virus Infection Model. J Vaccines Vaccin 3:150. doi:10.4172/2157-7560.1000150

Copyright: © 2012 Kato K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Epstein–Barr virus (EBV) is a ubiquitous herpes virus that usually infects humans asymptomatically, occasionally inducing various EBV-associated diseases, including infectious mononucleosis (IM), chronic active EBV infection, and different types of malignant tumors. A history of IM is associated with a 3-fold increased risk for subsequent EBV-related Hodgkin lymphoma. In immunocompromised individuals or transplant patients, EBV presents a high risk for morbidity and mortality, although prophylactic vaccination against EBV might contribute to reduce this risk. In this study, we used a rabbit EBV infection model to determine whether vaccination with synthesized peptides based on gp350/220 sequences could effectively prevent EBV infection or decrease the rate or degree of EBV infection. Six rabbits vaccinated with EBV gp350-peptides and four controls were challenged with a minimum dose of EBV infection; EBV-DNAs or EBV-RNAs were detected in 5/6 and 4/4 rabbits, respectively. This suggested that a gp350-peptide vaccine could not prevent primary EBV infections in rabbits and indicated the presence of EBV infection routes or mechanisms in rabbits other than the gp350-CD21 interaction observed in EBV infection of human B-cells. However, this vaccine probably has the efficacy to control the viral loads in inoculated rabbits, because 5 out of 6 vaccinated rabbits showed no detectable EBV-DNA in their blood and either no or only few EBER-1-positive lymphocytes in the lymphoid tissues. This vaccine was immunogenic; however, developing other improved vaccines or adjuvants will be necessary to reduce EBV-related diseases.

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