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Systemic Inflammation and#8211; Impact on Tumor Biology and Outcomes in Colorectal Cancer | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Systemic Inflammation – Impact on Tumor Biology and Outcomes in Colorectal Cancer

Michael Lam1, Jeanne Tie1,2,3, Belinda Lee1,3, Jayesh Desai1,3, Peter Gibbs1,2,3 and Ben Tran1,2,3*
1Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Australia
2Department of Medical Oncology, Western health, Footscray, Australia
3Division of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Corresponding Author : Ben Tran
Department of Medical Oncology
Royal Melbourne Hospital
Parkville, VIC, 3050, Australia
Tel: +61-3-9342-7560
Fax: +61-3-9347-7508
E-mail: [email protected]
Received: October 15, 2015 Accepted: December 14, 2015 Published: December 28, 2015
Citation: Lam M, Tie J, Lee B, Desai J, Gibbs P, et al. (2015) Systemic Inflammation – Impact on Tumor Biology and Outcomes in Colorectal Cancer. J Clin Cell Immunol 6:377. doi:10.4172/2155-9899.1000377
Copyright: © 2015 Lam M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Inflammation is increasingly recognized as a major factor in cancer development and progression. While local inflammation, represented by higher density of tumor infiltrating immune cells, is associated with better outcomes, the presence of systemic inflammation is conversely associated with poorer outcomes. This has been studied extensively in colorectal cancer where surrogates of systemic inflammation, such as serum albumin, C-reactive peptide, neutrophils and lymphocytes, have been shown to have prognostic significance independent of traditional clinicopathological factors. Despite the strength of this clinical data, the biological mechanisms underlying the poor outcomes are not well understood. This review details the impact of systemic inflammation on outcomes in colorectal cancer and examines what is known about the underlying biology.