Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases
|Thabet Y1#, Mankaï A1,2#, Achour A1, Sakly W1, Trabelsi A1, Harbi A3, Amri F4, Sfar MT5 and Ghedira I1,6*|
|1Research unit (03/UR/07-02), Faculty of pharmacy, Monastir, Tunisia|
|2High School of Sciences and Techniques of Health, Tunis el Manar University, Tunisia|
|3Pediatric Department, Sahloul Hospital, Sousse, Tunisia|
|4Pediatric Department, Ibn El Jazzar Hospital, Kairouan, Tunisia|
|5Pediatric Department, Tahar Sfar Hospital, Mahdia, Tunisia|
|6Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia|
|#Thabet Y and Mankaï A contributed equally to this work|
|Corresponding Author :||Ibtissem Ghedira
Laboratory of Immunology, Farhat Hached Hospital
Avenue Ibn El Jazzar, 4000 Sousse, Tunisia
Tel: (216) 73221411
Fax: (216) 73461830
E-mail: [email protected]
|Received December 30, 2013; Accepted February 19, 2014; Published February 26, 2014|
|Citation: Thabet Y, Mankaï A, Achour A, Sakly W, Trabelsi A, et al. (2014) Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases. J Clin Cell Immunol 5:192. doi:10.4172/2155-9899.1000192|
|Copyright: © 2014 Thabet Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Aim: To determine the clinical and serological characteristics in pediatric systemic lupus erythematosus (SLE).
Patients and methods: This retrospective study included 37 patients with SLE. All patients fulfilled the ACR revised criteria for SLE and diagnosed between 1994 and 2009. Anti-nuclear antibodies were detected by indirect immunofluorescence (IIF) on liver rat sections. Anti-dsDNA, anti-Sm, anti-nucleosome, anti-SSA, anti-SSB and anti- RNP antibodies were detected by ELISA. Anti-dsDNA antibodies were detected also by IIF on Chrithidia luciliae.
Results: The most common signs were anemia (86.5%), proteinuria (73%) and malar rash (67.6%). The frequency of arthritis and photosensitivity were 45.9% and 43.2% respectively. Leucopenia, thrombocytopenia and oral ulcer were present in 37.8%, 32.4% and 18.9% of cases respectively. The frequency of discoid rash was 13.5%. Anti-dsDNA antibodies were detected in 81.1%, anti-Sm and anti-RNP in 56.8%, anti-SSA in 43.2% and anti-SSB in 35.1%.
Conclusion: The highest frequency of childhood SLE is situated at the age of puberty. Renal disease is very frequent in paediatric SLE.