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Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases

Thabet Y1#, Mankaï A1,2#, Achour A1, Sakly W1, Trabelsi A1, Harbi A3, Amri F4, Sfar MT5 and Ghedira I1,6*
1Research unit (03/UR/07-02), Faculty of pharmacy, Monastir, Tunisia
2High School of Sciences and Techniques of Health, Tunis el Manar University, Tunisia
3Pediatric Department, Sahloul Hospital, Sousse, Tunisia
4Pediatric Department, Ibn El Jazzar Hospital, Kairouan, Tunisia
5Pediatric Department, Tahar Sfar Hospital, Mahdia, Tunisia
6Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia
#Thabet Y and Mankaï A contributed equally to this work
Corresponding Author : Ibtissem Ghedira
Laboratory of Immunology, Farhat Hached Hospital
Avenue Ibn El Jazzar, 4000 Sousse, Tunisia
Tel: (216) 73221411
Fax: (216) 73461830
E-mail: [email protected]
Received December 30, 2013; Accepted February 19, 2014; Published February 26, 2014
Citation: Thabet Y, Mankaï A, Achour A, Sakly W, Trabelsi A, et al. (2014) Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases. J Clin Cell Immunol 5:192. doi:10.4172/2155-9899.1000192
Copyright: © 2014 Thabet Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Aim: To determine the clinical and serological characteristics in pediatric systemic lupus erythematosus (SLE).

Patients and methods: This retrospective study included 37 patients with SLE. All patients fulfilled the ACR revised criteria for SLE and diagnosed between 1994 and 2009. Anti-nuclear antibodies were detected by indirect immunofluorescence (IIF) on liver rat sections. Anti-dsDNA, anti-Sm, anti-nucleosome, anti-SSA, anti-SSB and anti- RNP antibodies were detected by ELISA. Anti-dsDNA antibodies were detected also by IIF on Chrithidia luciliae.

Results: The most common signs were anemia (86.5%), proteinuria (73%) and malar rash (67.6%). The frequency of arthritis and photosensitivity were 45.9% and 43.2% respectively. Leucopenia, thrombocytopenia and oral ulcer were present in 37.8%, 32.4% and 18.9% of cases respectively. The frequency of discoid rash was 13.5%. Anti-dsDNA antibodies were detected in 81.1%, anti-Sm and anti-RNP in 56.8%, anti-SSA in 43.2% and anti-SSB in 35.1%.

Conclusion: The highest frequency of childhood SLE is situated at the age of puberty. Renal disease is very frequent in paediatric SLE.