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ISSN: 2161-0444

Medicinal Chemistry
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Review Article

Systems Biology and Systems Medicine: The Technological Tools of the System Approaches to Complexity

Alessandra Del Bufalo1, Patrizia Russo1*, Mirta Milic1,2, Christian Pristipino3, Massimo Fini4 and Alfredo Cesario5

1Laboratory of Systems Approaches and Non Communicable Diseases, IRCCS "San Raffaele Pisana", Rome, Italy

2Mutagenesis Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia

3Personalized and Systems Medicine Unit, San Filippo Neri Hospital, Rome, Italy

4Scientific Director, IRCCS “San Raffaele Pisana”, Rome, Italy

5Deputy Scientific Director and Coordinator, Area of Systems Medicine, IRCCS “San Raffaele Pisana”, Rome, Italy

*Corresponding Author:
Patrizia Russo, PhD
Chief, Laboratory of Systems Approaches and Non Communicable Diseases
IRCCS "San Raffaele Pisana" Via di Valcannuta
247, I-00166 Roma, Italia
Tel: 393483339704
E-mail:[email protected], [email protected]

Received date: February 21, 2014; Accepted date: May 19, 2014; Published date: May 21, 2014

Citation: Del Bufalo A, Russo P, Milic M, Pristipino C, Fini M, et al. (2014) Systems Biology and Systems Medicine: The Technological Tools of the System Approaches to Complexity. Med chem 4:473-480. doi:10.4172/2161-0444.1000181

Copyright: © 2014 Del Bufalo A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Progresses made in “omics” research have fueled the collection and storage of large quantities of data. Now these data can be used for knowledge gaining. Systems biology aims at studying biological organisms as interconnected systems. Systems Medicine, by applying systems biology approaches, tries to understand illness in the context of altered regulatory circuitry. Studies in a Systems Medicine framework will enable a better understanding of diseases, and the delivery of a personalized healthcare, tailored on the specific phenotype of each single patient. In this relatively new discipline, the review describes those tools useful in this approach.


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