alexa Syzigium cumini and Mangifera indica Seed Extracts: In Vitro Assessment for Antibacterial Activity Alone and in Combination with Antibiotics against Clinical Bacteria
ISSN: 2329-8731

Journal of Infectious Diseases & Preventive Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Syzigium cumini and Mangifera indica Seed Extracts: In Vitro Assessment for Antibacterial Activity Alone and in Combination with Antibiotics against Clinical Bacteria

Malay Kumar Das and Shyamapada Mandal*

Department of Zoology, University of Gour Banga, India

*Corresponding Author:
Shyamapada Mandal
Laboratory of Microbiology and Experimental Medicine
Department of Zoology
University of Gour Banga
Malda- 732103
Tel: 91-9831279239
E-mail: [email protected]

Received date: May 30, 2016; Accepted date: July 06, 2016; Published date: July 13, 2016

Citation: Das MK, Mandal S (2016) Syzigium cumini and Mangifera indica Seed Extracts: In Vitro Assessment for Antibacterial Activity Alone and in Combination with Antibiotics against Clinical Bacteria. J Infect Dis Preve Med 4:129. doi:10.4172/2329-8731.1000129

Copyright: © 2016 Das MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: To determine the antibacterial activity of Syzigium cumini (Family: Myrtaceae) and Mangifera indica (Family: Anacardiaeceae) seed extracts, alone and in combination with some conventionally used antibiotics, against clinical isolates of Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. Method: The antibacterial activity of ethanolic S. cumini seed extract (SSE) and M. indica seed extract (MSE), at different concentrations, were determined by disk diffusion. The combined activity with antibiotics of the extracts (SSE and MSE) was determined against the test isolates. The ZDI (zone diameter of inhibition) values for the agents (alone and in combination) were recorded, and growth inhibitory indices (GIIs) were calculated. Result: The bacterial isolates were multidrug resistant, against which the SSE and MSE had excellent activity; ZDIs of SSE and MSE for E. coli and K. Pneumoniae ranged 8 - 20 mm, whereas for Staph. aureus ZDIs were 8 - 18 mm. The extracts (SSE and MSE) in combination with trimethoprim and vancomycin showed synergistic effect against all the test bacteria (GIIS: 0.53–1.0). The extracts, combined with ampicillin, ciprofloxacin and methicillin, had mixed interaction: synergistic (GIIs: 0.53–1.0) as well as antagonistic (GIIs: 0.37–0.47) against the test strains. Conclusion: The plant extracts (SSE and MSE), having broad antibacterial activity alone, and synergistic interaction in combination with antibiotics against the human pathogenic bacteria, might be useful in preparing nonantibiotic as well as combined treatment regimen against bacterial infection to humans.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version