alexa T Cell Co-inhibitory Receptors-Functions and Signalling Mechanisms
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

T Cell Co-inhibitory Receptors-Functions and Signalling Mechanisms

Thilipan Thaventhiran, Swaminathan Sethu, Han Xian Aw Yeang, Laith Al-Huseini, Junnat Hamdam and Jean G Sathish*
Department of Molecular & Clinical Pharmacology and the MRC Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, UK
Corresponding Author : Jean G Sathish
Department of Molecular & Clinical Pharmacology and the MRC Centre for Drug Safety Science
University of Liverpool
Sherrington Buildings, Ashton Street
Liverpool L69 3GE, UK
Tel: 0044 1517945477
E-mail: [email protected]
Received September 17, 2012; Accepted October 10, 2012; Published October 17, 2012
Citation: Thaventhiran T, Sethu S, Yeang HXA, Al-Huseini L, Hamdam J, et al. (2012) T Cell Co-inhibitory Receptors: Functions and Signalling Mechanisms. J Clin Cell Immunol S12:004. doi:10.4172/2155-9899.S12-004
Copyright: © 2012 Thaventhiran T, et al, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

T cell activation is a central event in the adaptive immune response and essentially begins with the recognition of an antigenic peptide in the context of a major histocompatibility complex (MHC) on an antigen-presenting cell by the T cell receptor (TCR). The process of T cell activation consists of an orchestration of various functional modules such as actin polymerization, cell surface receptor patterning, calcium fluxing, immunological synapse formation, enhanced adhesion and gene transcription. These modules are mediated by a number of signalling proteins through inducible phosphorylation, enzyme activation and protein-protein & protein-lipid interactions. This complex and dynamic interplay of signalling events governs the decisions the T cell makes in terms of gene expression, proliferation, differentiation, survival and migration. These outcomes are influenced by the magnitude, duration and context of the activation signals. The activation signals have the potential to be modulated by a family of receptors termed, co-inhibitory receptors that include PD-1, LAG-3, TIM-3 and CTLA-4. Co-inhibitory receptors modulate signalling by utilising mechanisms such as ectodomain competition with counter receptors and by the use of intracellular mediators such as protein phosphatases. Co-inhibitory receptors can act as threshold-setters, modulators, check-points and feedback mechanisms that can potentially fine tune the quality and magnitude of the T cell immune response. Given the key roles of these receptors in modulating the immune response, they are increasingly being targeted for immune intervention in a variety of disease settings. This review discusses current understanding of the role of co-inhibitory receptors in influencing T cell signalling.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords