alexa T cell Receptor Signal Transduction in T lymphocytes | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

T cell Receptor Signal Transduction in T lymphocytes

Balachandra K Gorentla1* and Xiao-Ping Zhong2,3*
1Pediatric Biology Center, Translational Health Science and Technology Institute, Gurgaon, 122016, India
2Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
3Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
Corresponding Authors: Xiao-Ping Zhong, MD, PhD
Department of Pediatrics- Allergy and Immunology
Rm 133 MSRB, Research Drive, Box 2644
Duke University Medical Center
Durham, NC 27710, USA
Tel: 919-681-9450
Fax: 919-668-3750
E-mail: [email protected]
  Balachandra Gorentla, PhD
Pediatric Biology Center
Translational Health Science and Technology Institute
# 496, Phase-III, Udyog Vihar
Gurgaon -122016, Haryana, India
E-mail: [email protected]
Received September 06, 2012; Accepted October 20, 2012; Published October 27, 2012
Citation: Gorentla BK, Zhong XP (2012) T cell Receptor Signal Transduction in T lymphocytes. J Clin Cell Immunol S12:005 doi: 10.4172/2155-9899.S12-005
Copyright: © 2012 Gorentla BK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The T cell receptor (TCR) recognizes self or foreign antigens presented by major histocompatibility complex (MHC) molecules. Engagement of the TCR triggers the formation of multi-molecular signalosomes that lead to the generation of second messengers and subsequent activation of multiple distal signaling cascades, such as the Ca+2-calcineurin-NFAT, RasGRP1-Ras-Erk1/2, PKCθ-IKK-NFκB, and TSC1/2-mTOR pathways. These signaling cascades control many aspects of T cell biology. Mechanisms have been evolved to fine-tune TCR signaling to maintain T cell homeostasis and self-tolerance, and to properly mount effective responses to microbial infection. Defects or deregulation of TCR signaling has been implicated in the pathogenesis of multiple human diseases.

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