alexa T cell-Associated Cytokines in the Pathogenesis of SjÃ
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

T cell-Associated Cytokines in the Pathogenesis of Sjögren’s Syndrome

Jun-O Jin and Qing Yu*
Department of Immunology and Infectious Disease, the Forsyth Institute, 245 First Street, Cambridge, MA, USA
Corresponding Author : Qing Yu
Department of Immunology and Infectious Disease
the Forsyth Institute, 245 First Street
Cambridge, MA 02142, USA
Tel: 617-892-8310
Fax: 617-892-84372
E-mail: [email protected]
Received November 21, 2012; Accepted February 19, 2013; Published February 26, 2013
Citation: Jin JO, Yu Q (2013) T cell-Associated Cytokines in the Pathogenesis of Sjögren’s Syndrome. J Clin Cell Immunol S1:009. doi:10.4172/2155-9899.S1-009
Copyright: © 2013 Jin JO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Sjögren’s syndrome (SjS) is a systemic autoimmune disease that primarily targets salivary and lacrimal glands. SjS affects 2-4 million people in the US alone and greatly affects the life quality of the afflicted individuals. Autoreactive effector T cells are central executors and orchestrators in the pathogenic processes of SjS by mediating target organ inflammation and destruction and by facilitating B cell responses and autoantibody production. A variety of cytokines that are produced by effector T cells or capable of directly affecting effector T cells are elevated in the target organs and circulations of SjS patients. The recent advancement in the understanding about the functions of these cytokines, achieved by using both human samples and mouse disease models, has generated great insights into the cytokine control of autoimmune responses in the SjS disease setting. In this review, we summarized the recent findings on the expression and functions of cytokines in this disease, with specific focus on those derived from T cells and/or directly affecting T cell responses.

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