T Cell-Derived GM-CSF, Regulation of Expression and Function
- *Corresponding Author:
- Yongliang Zhang
Department of Microbiology
Yong Loo Lin School of Medicine
National University of Singapore, Singapore
Tel: +216 73 22 14 11
E-mail: [email protected]
Received date: July 30, 2015 Accepted date: August 19 2015 Published date: August 24, 2015
Citation: Sheng W, PNG CW, Reynolds JM, Zhang Y (2015) T Cell-Derived GM-CSF, Regulation of Expression and Function. Immunome Res 11:098. doi:10.4172/1745-7580.1000098
Copyright: © 2015 Sheng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is produced by a variety of cells and plays an important role in the inflammatory response in infection as well as in autoimmunity. Recent progress has indicated that CD4+ T cell-derived GM-CSF has a prominent and non-redundant function in mediating autoimmune neuroinflammation. Thus, there is increased interest on studying the regulation of GM-CSF production by T helper cells, which could translate to the development of novel therapeutics for autoimmune diseases such as multiple sclerosis. This review focuses on our current understanding of the regulation and function of T cell-derived GM-CSF.