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ISSN: 1745-7580

Immunome Research
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Review Article

T Cell-Derived GM-CSF, Regulation of Expression and Function

Wanqiang Sheng1, Chin Wen PNG2,3, Joseph M Reynolds4, and Yongliang Zhang2,3*

1Cancer Science Institute of Singapore, National University of Singapore, Singapore

2Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

3Immunology Programme, Life Science Institute, National University of Singapore, Singapore

4Department of Microbiology & Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA

*Corresponding Author:
Yongliang Zhang
Department of Microbiology
Yong Loo Lin School of Medicine
National University of Singapore, Singapore
Tel: +216 73 22 14 11
E-mail: [email protected]

Received date: July 30, 2015 Accepted date: August 19 2015 Published date: August 24, 2015

Citation: Sheng W, PNG CW, Reynolds JM, Zhang Y (2015) T Cell-Derived GM-CSF, Regulation of Expression and Function. Immunome Res 11:098. doi:10.4172/1745-7580.1000098

Copyright: © 2015 Sheng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is produced by a variety of cells and plays an important role in the inflammatory response in infection as well as in autoimmunity. Recent progress has indicated that CD4+ T cell-derived GM-CSF has a prominent and non-redundant function in mediating autoimmune neuroinflammation. Thus, there is increased interest on studying the regulation of GM-CSF production by T helper cells, which could translate to the development of novel therapeutics for autoimmune diseases such as multiple sclerosis. This review focuses on our current understanding of the regulation and function of T cell-derived GM-CSF.

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