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T cells in Immunobiology of Tumors and Immunotherapy | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

T cells in Immunobiology of Tumors and Immunotherapy

Vino T Cheriyan1*, Christella John Nelson1 and Prabha Balaram2*
1Karmanos Cancer Centre, School of Medicine, Wayne State University, Detroit, MI, USA
2Division of Cancer Research, Regional Cancer Centre, Trivandrum, Kerala, India
*Corresponding Authors : Vino T Cheriyan
B4325, 4646 John R
Detroit, 48026, MI, USA
Tel: 586-277-9973
Fax: 313-576-1112
E-mail: [email protected]
  Professor Prabha Balaram
(retd) Akshaya, MRA 50, Madathuvila lane
Medical college P.O, Trivandrum, 695011, Kerala, India
Tel: +919946405176
E-mail: [email protected]
Received: November 20, 2015 Accepted: February 08, 2016 Published: February 11, 2016
Citation: Cheriyan VT, Nelson CS, Balaram P (2016) T cells in Immunobiology of Tumors and Immunotherapy. J Clin Cell Immunol 7:392. doi:10.4172/2155-9899.1000392
Copyright: © 2016 Cheriyan VT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Recent studies indicate that functional T-lymphocyte defects compromise anti-tumor responses in various cancers. It appears that tumors not only effectively bypassed the host immune system, but have also actively corrupted the host anti-tumor response via several distinct mechanisms. Cancer Immunotherapy has made significant strides in recent years, due to improved understanding of the underlying principles of tumor biology and immunobiology. This review attempts to identify strategic factors involved in anti-cancer immune impairment, understand the mechanisms underlying reported immunosuppression and highlight some of the most promising present day immunotherapy approaches progressing successfully in clinics.


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