alexa T11TS Induced Modulation of Macrophages Associated Cyto
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

T11TS Induced Modulation of Macrophages Associated Cytokines TNF-α,VEGF and Apoptototic Protein Bax, Bcl2 Abrogates Tumor Cells in In vitro Grade I,II Human Glioma

Pankaj Kumar1, Sirshendu Chatterjee1, Sagar Acharya1,3, Annpurna Kumari1, Suhnrita Chaudhuri1, Manoj Kumar Singh1, Samarendra Nath Ghosh2, Swapna Chaudhuri1*
1Department of Laboratory Medicine, School of Tropical Medicine, 108 Chittaranjan Avenue, Kolkata-700073, India
2Department of Neurosurgery, Bangur Institute of Neurology & Psychiatry, Institute of Postgraduate Medical Education & Research , Kolkata-700020, India
3Department of Zoology, Vidyasagar University, Medinipore, India
Corresponding Author : Prof. Swapna Chaudhuri
Department of Laboratory Medicine, School of Tropical Medicine
108, Chittaranjan Avenue, Kolkata-700073
West Bengal, India
Tel: +91-033-2241-4065 (Ext. 207)
Fax: +91-033-2241-4915
E-mail: [email protected]
Received November 19, 2012; Accepted January 17, 2013; Published January 24, 2013
Citation: Kumar P, Chatterjee S, Ghosh SN, Acharya S, Kumari A, et al. (2013) T11TS Induced Modulation of Macrophages Associated Cytokines TNF-α, VEGF and Apoptototic Protein Bax, Bcl2 Abrogates Tumor Cells in In vitro Grade I,II Human Glioma. J Clin Cell Immunol S1:006 doi:10.4172/2155-9899.S1-006
Copyright: © 2013 Kumar P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

T11 target structure (T11TS), a membrane glycoprotein has been documented with anti-neoplastic activity in glioma bearing animal model in our lab. In this study, we have evaluated the phagocytic potential, expression of VEGF, TNF-α in T11TS treated and untreated macrophages in all four grades of glioma. The data indicates the significant enhancement of phagocytosis in T11TS treated macrophages of Grade I and II glioma. There was significant upregulation in TNF-α and significant down-regulationin VEGF expression in T11TS treated macrophages in grade I and II glioma.We alsoattempted to know any possible apoptotic role of T11TS in tumor cell by comparing Bax and Bcl2 in treated and untreated tumour cell of all four grades. We found significant up-regulation in Bax expression and down-regulation in Bcl2 expression of grade I and II glioma. The outcome may help in pushing this molecule into pharmaceutical domain.

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