alexa Tablet Formulation and Enhancement of Aqueous Solubilit
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Tablet Formulation and Enhancement of Aqueous Solubility of Efavirenz by Solvent Evaporation Co-Crystal Technique

Vikas G Rajurkar*, Nagare Amit Sunil and Vilas Ghawate

MES College of Pharmacy, Savitribai Phule Pune University, Sonai, Ahmednagar, Maharashtra, India

*Corresponding Author:
Rajurkar VG
Professor, Quality Assurance Department
MES College of Pharmacy, Sonai-414 105
Taluka-Newasa, District-Ahmednagar Maharashtra, India
Tel: +919860482926
E-mail: [email protected]

Received date: August 02, 2015; Accepted date: September 01, 2015; Published date: September 07, 2015

Citation: Rajurkar VG, Sunil NA, Ghawate V (2015) Tablet Formulation and Enhancement of Aqueous Solubility of Efavirenz by Solvent Evaporation Co- Crystal Technique. Med chem S2:002. doi: 10.4172/2161-0444.1000002

Copyright: © 2015 Rajurkar VG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited.

 

Abstract

 

Improvement in the aqueous solubility,physicochemical and micromeritics property of insoluble and slightly soluble drugs is of major concern in pharmaceutical formulations. It is commonly observed in the drug industry that on average more than 35% of newly discovered drugs are poorly water-soluble. Poor “drug like” properties of lead compounds led to ineffective absorptionfrom the site of administration, less bioavailability which has been designated as an important part of the high clinical failure. In the present work, Efavirenz, nonnucleoside reverse transcriptase inhibitors (NNRTIs) in first-line antiretroviral therapy (ART) belongs to BCS class II drug (highly permeable and low soluble). A simultaneous DSC, FT-IR, SEM, XRPD micro spectroscopy, dissolution study and micromeritics properties studies was used to quickly investigate the co-crystal. Tablet formulation was developed by direct compression method and there evaluation was performed.

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