alexa Targeted Delivery of Paromomycin to Leishmania Infected Macrophage by Hemoglobin Tagged Nanocarrier | OMICS International | Abstract
ISSN: 1920-4159

Journal of Applied Pharmacy
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Short Communication

Targeted Delivery of Paromomycin to Leishmania Infected Macrophage by Hemoglobin Tagged Nanocarrier

Prakash Kumar2 and Partha Pratim Bose1,2*

1Bose Institute, Division of Molecular Medicine, Kolkata -700054, India

2National Institute of Pharmaceutical Education and Research, Department of Biotechnology, Hajipur, E.P.I.P complex, Bihar-844102, India

*Corresponding Author:
Partha Pratim Bose
Division of Molecular Medicine
Bose Institute, Kolkata-700054, India
Tel: 09470817905
E-mail: [email protected], [email protected]

Received date: December 21, 2015; Accepted date: January 12, 2016; Published date: January 16, 2016

Citation: Kumar P, Bose PP (2016) Targeted Delivery of Paromomycin to Leishmania Infected Macrophage by Hemoglobin Tagged Nanocarrier. J App Pharm 8:212. doi: 10.4172/1920-4159.1000212

Copyright: © 2016 Kumar P et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: After the extensive resistance of the first line of antimonial drugs, paromomycin, the broad-spectrum antibiotic has become the treatment of choice against visceral leishmaniasis, the fatal tropical disease. However, unfavorable distribution in the intracellular compartment of macrophage, prolonged parenteral administration procedure and toxicity limit the use of paromomycin. Lack of availability of specific delivery system also makes this drug unsafe. Thus, a specific and nontoxic formulation of paromomycin is an urgent need.

Materials and method: A chitosan-chondroitin sulfate based nano-formulation has been developed and hemoglobin has been tagged on the surface of the delivery system for the specific carriage of paromomycin to the leishmania infected macrophage taking the advantage of Leishmania being highly auxotrophic for heme.

Results: There has been a significant improvement in the toxicity profile with lowered LD50 value of nanoformulated paromomycin (75 μM) compared to the direct administration (130 μM).

Conclusion: A cheap, biodegradable, nontoxic and specific nano-carrier has been introduced for specific delivery of paromomycin to infected macrophages

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