alexa Targeted Therapy of Soft Tissue Sarcoma: There is More
ISSN: 2167-7700

Chemotherapy: Open Access
Open Access

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Review Article

Targeted Therapy of Soft Tissue Sarcoma: There is More than one Way to Skin a Cat!

Jyoti Bajpai* and Vaibhav Choudhary

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Corresponding Author:
Jyoti Bajpai
Department of Medical Oncology
Tata Memorial Hospital, Mumbai, 400012 India
Tel: +9920640040
Fax: 022-24177287
E-mail: [email protected]

Received Date: July 19, 2016; Accepted Date: October 15, 2016; Published Date: October 24, 2016

Citation: Bajpai J, Choudhary V (2016) Targeted Therapy of Soft Tissue Sarcoma: There is More than one Way to Skin a Cat!. Chemo Open Access 5:216. doi: 10.4172/2167-7700.1000216

Copyright: © 2016 Bajpai J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Soft tissue sarcomas are an uncommon and diverse group of more than 50 mesenchymal malignancies with very specific underlying molecular events driving oncogenesis. The mysterious pathogenesis is slowly revealing the vary secrets of their inner workings. There is a paradigm shift in sarcoma management wherein therapeutic decisionmaking is guided by key genetic events of oncogenic potential. Present perspective, will focus on the rationale for targeted delivery of therapy in sarcoma, with emphasis on the relevance of specific molecular factors and pathways. It will also focus upon the story behind some of the early successes and challenges and disappointments in taming these targets. Finally it will discuss possible opportunities represented by poorly understood, but potentially promising new therapeutic targets and investigational biological agents. This communication will provide a demarche of the current state of the art for medical management of sarcomas and a sense of where it may be headed in the coming years.

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