Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival SignalsFederica Frezzato1,2*, Valentina Trimarco1,2, Andrea Visentin1,2, Veronica Martini1,2, Filippo Severin1,2, Monica Facco1,2, Gianpietro Semenzato1,2 and Livio Trentin1,2
- *Corresponding Author:
- Federica Frezzato
Department of Medicine, Hematology and Clinical Immunology Unit
University of Padua, Italy
E-mail: [email protected]
Received date: February 16, 2016; Accepted date: March 18, 2016; Published date: March 21, 2016
Citation: Frezzato F, Trimarco V, Visentin A, Martini V, Severin F, et al. (2016) Targeting Bruton’s Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals. J Leuk 4:207. doi:10.4172/2329-6917.1000207
Copyright: © 2016 Frezzato F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments. The main goal of the researchers in CLL is the identification of specific targets in order to develop new therapeutic strategies to cure the disease. The Bcell receptor-signalling pathway is necessary for survival of malignant B cells and its related molecules recently become new targets for therapy. Moreover, leukemic microenvironment delivers survival signals to neoplastic cells also overcoming the apoptotic effect induced by traditional drugs. In this context, the investigation of Bruton’s tyrosine kinase (Btk) is useful in: i) dissecting CLL pathogenesis; ii) finding new therapeutic approaches striking simultaneously intrinsic as well as extrinsic pro-survival signals in CLL. This paper will review these main topics.