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ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

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Review Article

Targeting Cancer Stem Cells with Nanoparticle-Enabled Therapies

Andrew R. Burke1, Ravi N. Singh2, David L. Carroll3, Frank M. Torti4 and Suzy V. Torti5*

1Tumor Angiogenesis Section, Mouse Cancer Genetics Program, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, USA

2Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA

3Department of Physics, Wake Forest University, Winston Salem, NC 27109, USA

4Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, 06030, USA

5Department of Molecular, Microbial and Structural Biology, University of Connecticut School of Medicine, Farmington, CT, 06030, USA

*Corresponding Author:
Suzy V. Torti
Department of Molecular
Microbial and Structural Biology
University of Connecticut School of Medicine
263 Farmington Avenue, Farmington, CT 06030, USA
E-mail: [email protected]

Received date: June 01, 2012; Accepted date: June 25, 2012; Published date: July 02, 2012

Citation: Burke AR, Singh RN, Carroll DL, Torti FM, Torti SV (2012) Targeting Cancer Stem Cells with Nanoparticle-Enabled Therapies. J Mol Biomarkers Diagn S8:003. doi:10.4172/2155-9929.S8-003

Copyright: © 2012 Burke AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Emerging evidence suggests that multiple tumor types are sustained by a small population of transformed stemlike cells that have the ability to both self-renew and give rise to non-tumorigenic daughter cells that constitute the bulk of a tumor. These cells, which generally constitute a minority of the overall cancer cell population, are highly resistant to conventional therapies and persist following treatment, leading to disease relapse and the formation of distant metastases. Therapies that disrupt the maintenance and survival of cancer stem cells are the subject of active current investigation. This review discusses recent approaches to the application of nanomedicine to the targeting and elimination of cancer stem cells. Specifically, recent publications in the areas of nanoparticle-enabled drug and nucleic acid delivery and photothermal therapy are addressed.

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