alexa Targeting Gene Fusion Events in Bladder Carcinoma | OMICS International| Abstract

ISSN: 1747-0862

Journal of Molecular and Genetic Medicine

  • Mini Review   
  • J Mol Genet Med 2018, Vol 12(3): 361
  • DOI: 10.4172/1747-0862.1000361

Targeting Gene Fusion Events in Bladder Carcinoma

Sharma J1,2, Gondkar K1,3, Deb B1,2 and Kumar P1,2*
1Institute of Bioinformatics, International Technology Park, Bangalore, India
2Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India
3Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India
*Corresponding Author : Dr. Kumar P, Institute of Bioinformatics, International Technology Park, Bangalore- 560066, India, Tel: (+91) 80-28416140, Email: [email protected]

Received Date: Aug 24, 2018 / Accepted Date: Sep 03, 2018 / Published Date: Sep 06, 2018

Abstract

Studies over the past decades revealed the driving role of fusion genes in tumorigenesis. With the advent of sequencing methods, a surge in the identification of novel fusions genes has been evident. These events may also rearrange gene promoters to amplify the expression of oncogenes or to decrease the expression of tumor suppressor genes. Several gene fusion events are determined in bladder carcinoma including well characterized FGFR3–TACC3 and FGFR3–BAIAP2L1 fusion genes. These fusion genes generate chimeric proteins which retain the complete sequence of FGFR3 except the final exon fused in-frame to different C-terminal regions of the TACC3 and BAIAP2L1. The presence of fusion genes offers promising targetable molecules for treatment, resulting improved patient outcome. Oncogenic FGFR3 is a druggable gene fusion signifying that it may aid in selection of patients for FGFR-targeted therapy in bladder carcinoma.

Keywords: Urothelial carcinoma; Next-generation sequencing; FGF receptor; Clinical trial

Citation: Sharma J, Gondkar K, Deb B, Kumar P (2018) Targeting Gene Fusion Events in Bladder Carcinoma. J Mol Genet Med 12: 361 Doi: 10.4172/1747-0862.1000361

Copyright: © 2018 Sharma J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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