alexa Targeting of the Adenosine Receptors as A Novel Strategy for the Treatment of Arterial Hypertension
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Targeting of the Adenosine Receptors as A Novel Strategy for the Treatment of Arterial Hypertension

Gisele Zapata-Sudo1*, Susumu Z Sudo2, Allan K.N. Alencar1 and Roberto T Sudo1

1Programa de Desenvolvimento de Farmacos, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

2Fundacao Tecnico Educacional Souza Marques, Escola de Medicina, Rio de Janeiro, RJ, Brazil

Corresponding Author:
Dr. Gisele Zapata-Sudo
Universidade Federal do Rio de Janeiro
Centro de Ciencias da Saude, Instituto de Ciencias Biomedicas
Bloco J, Sala 14, Rio de Janeiro, RJ
Brazil, 21941-590
PH/FAX 55-21-25626505
E-mail: [email protected]

Received date: August 04, 2014; Accepted date: October 29, 2014; Published date: November 05, 2014

Citation: Zapata-Sudo G, Sudo SZ, Alencar AKN, Sudo RT (2014) Targeting of the Adenosine Receptors as A Novel Strategy for the Treatment of Arterial Hypertension . J Neurol Neurophysiol 5:243 doi:10.4172/2155-9562.1000243

Copyright: © 2014 Zapata-Sudo G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: The effects of loud noise (80 dB) on neurogenesis in the sub-ventricular zone (SVZ) and the
hippocampal sub-granular zone (SGZ) was investigated in vivo in the rat brain using positron emission tomography
(PET) with 3’-deoxy-3’- [18F]fluoro-L-thymidine ( [18F]FLT), a marker for thymidine kinase I (TK-1) related to cell
proliferation and for neurogenesis in SVZ and SGZ.
Methods: Five young Sprague-Dawley rats were exposed to loud noise from two speakers set in front of their
cages during the night for 4 nights, and 5 control rats were exposed to normal quiet conditions. PET was performed
4 days after the exposure.
Results: The accumulation of [18F] FLT in SVZ was significantly lower in the rats with noise exposure than in the
control rats. The level of [18F] FLT uptake was lower in the SVZ than in the SGZ.
Conclusion: Our results indicate that loud noise exposure during the awake period may be related to the
decrease in proliferative capacity of neural stem cells especially in the SVZ of the living rat brain. This finding may
indicate that persistent loud noise during daily life is harmful to brain development in humans.

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