Targeting Oxidative Stress: A Novel Approach in Mitigating Cancer
Pritam Sadhukhan, Sukanya Saha and Parames C Sil*
Division of Molecular Medicine, Bose Institute, Kolkata, India
- *Corresponding Author:
- Parames C Sil
Division of Molecular Medicine
Bose Institute, Kolkata, India
E-mail: [email protected], par[email protected]
Received Date: November 30, 2015; Accepted Date: December 08, 2015; Published Date: December 31, 2015
Citation: Sadhukhan P, Saha S, Sil PC (2015) Targeting Oxidative Stress: A Novel Approach in Mitigating Cancer. Biochem Anal Biochem 4:236. doi:10.4172/2161-1009.1000236
Copyright: © 2015 Sadhukhan P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Reactive Oxygen Species (ROS) plays a vital role in normal cellular homeostasis and development of pathophysiological conditions. Researches round the globe suggest that cancer cell possesses higher amount of intracellular ROS and impaired metabolic activity along with mitochondrial dysfunction. ROS can initiate cancer, but the primary endogenous elevation of oxidants in malignant tissues leave them more susceptible to secondary stresses. Despite the crucial role of ROS in the development of cancer, anticancer therapies are suggested both by scavenging the excessive intracellular ROS and also by inducing ROS generation through exogenous oxidative insult. In this commentary, we have discussed the dual effect of ROS on the development cancer and emergence of novel anti-cancer therapies by modulating the accumulation of ROS.