alexa Targeting ROS for Cancer Therapy
ISSN: 2167-7700

Chemotherapy: Open Access
Open Access

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Targeting ROS for Cancer Therapy

MJingwu Dong1, Bin Liu2,3, and Runzhi Zhu1,2,4*

1Clinical Research Center, Xuyi People’s Hospital, Xuyi 211700, PR China

2Key Laboratory of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang Key Laboratory of Hepatobiliary Diseases, Zhanjiang 524001, PR China

3Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China

4Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA

*Corresponding Author:
Runzhi Zhu
Clinical Research Center of Xuyi People’s Hospital
28 Hongwu Road Xuyi Economic Development District
Xuyi, Jiangsu 211700,PR China
Tel: +52-662289 24 00
E-mail: [email protected]

Received date: March 26, 2016; Accepted date: April 28, 2016; Published date: May 02, 2016

Citation: Dong J, Liu, Zhu R (2016) Targeting ROS for Cancer Therapy. Chemo Open Access 5: 199. doi:10.4172/2167-7700.1000199

Copyright: © 2016 Dong J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Reactive oxygen species (ROS) act as a second messenger in cell signaling and participate in a variety of biological processes in normal cells. Under normal physiological conditions, ROS are produced and then eliminated by ROS scavenging system to maintain cellular redox balance. Levels of ROS could change with endogenous or exogenous reasons, leading to DNA damage, oxidative stress and abnormal cell signaling. Reduction of ROS could lead to interruption of cell signaling, thus influence the cellular homeostasis. Cancer cell metabolism that often appear in the redox imbalance and oxidative stress, in the situation, antioxidant mechanism needs to balance this pressure, which has been the symbol of tumorigenesis [


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