alexa Task Practice with or without Cellular Transplantation Promotes Recovery of Reach-to Grasp Function after Cervical Spinal Cord Injury
ISSN: 2329-9096

International Journal of Physical Medicine & Rehabilitation
Open Access

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Research Article

Task Practice with or without Cellular Transplantation Promotes Recovery of Reach-to Grasp Function after Cervical Spinal Cord Injury

Scott K. Stackhouse1,2 and Jed S. Shumsky2*

1Department of Physical Therapy, Arcadia University, Glenside, PA 19038, USA

2Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA

*Corresponding Author:
Jed S. Shumsky
Department of Neurobiology and Anatomy Drexel
University College of Medicine 2900 Queen Lane
Philadelphia, PA 19129, USA
Tel: 215-991-8736
Fax: 215-843-9082
E-mail: [email protected]

Received July 31, 2014; Accepted October 24, 2014; Published October 29, 2014

Citation: Stackhouse SK, Shumsky JS (2014) Task Practice with or without Cellular Transplantation Promotes Recovery of Reach-to Grasp Function after Cervical Spinal Cord Injury. Int J Phys Med Rehabil 2:239. doi: 10.4172/2329-9096.1000239

Copyright: © 2014 Stackhouse SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background and Purpose: Cervical spinal cord injury results in specific deficits in forelimb function. In the rat, lesions to the rubrospinal tract impair forelimb function despite the presence of an intact corticospinal tract. Both functional and anatomical recovery have been promoted by transplantation of neuronal and glial restricted precursors (NRP/GRP) following injury, and task-specific practice is used clinically to maximize recovery of function. We tested the hypothesis that combination therapy of daily task practice and NRP/GRP cell transplants will improve reach-to-grasp function. Methods: Forty-one adult female rats received a lesion to the right cervical dorsolateral funiculus. They were randomly divided into 4 groups for the study: Control (n=11), NRP/GRP Transplant (n=14), Task Practice (n=8), and Task Practice + NRP/GRP (n=8). All animals were assessed pre-injury and during weeks 1 and 8 postoperatively on two reach-to-grasp tests (Single Pellet and Staircase Reaching). Results: Task Practice + NRP/GRP and Task Practice groups achieved significant recovery of function in the Staircase Reaching test at week 8 of recovery. Analysis of individual kinematic elements from the Single Pellet Reaching test allows detailed quantitation of specific movements. While major differences were not observed in the Single Pellet Reaching, the Digits Open and Pronation qualitative component scores were higher in the Task Practice + NRP/GRP group compared to controls at 8 weeks post injury. Conclusions: While task practice improves recovery of forelimb function following incomplete spinal cord injury, combination therapy of daily task practice and cell transplantation practice did not result in superior recovery of reach-to-grasp function.

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