alexa Taste acceptance of Captopril and Furosemide Extemporan
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
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Research Article

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Medeiros MDSG1*, Garruti DDS2, Batista LAA3, Cruz Fonseca SGD4, Fernandes FP5, Luna Coelho HL6

1Postgraduate Programme in Pharmaceutical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil

2Laboratory of Sensory Analysis, Embrapa Tropical Agroindustry, Fortaleza, Ceará, Brazil

3Postgraduate Programme in Pharmaceutical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil

4Pharmacy Department, Federal University of Ceará, Fortaleza, Ceará, Brazil

5Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil

6Postgraduate Programme in Pharmaceutical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil

Corresponding Author:
Medeiros MDSG
Postgraduate Programme in Pharmaceutical Sciences
Federal University of Ceará
Fortaleza, Ceará, Brazil
Tel:+55 85981174135
E-mail: [email protected]

Received date: May 04, 2016; Accepted date: May 13, 2016; Published date: May 19, 2016

Citation: Medeiros MDSG, Garruti DDS, Batista LAA, Fonseca SGDC, Fernandes FP, et al. (2016) Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children. J Pharma Care Health Sys 3:156. doi: 10.4172/2376-0419.1000156

Copyright: © 2016 Medeiros MDSG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Many pediatric patients require medications that are not available in age appropriate formulations, especially those with cardiovascular diseases. The use of a suitable vehicle is critical for the preparation of extemporaneous formulations with the expected effect. Considering that palatability is essential to treatment adherence in children, we analyzed the acceptance of extemporaneous formulations of Captopril and Furosemide prepared using a developed vehicle in three flavors: neutral, strawberry and mint. Formulations were administered to hospitalized pediatric patients as prescribed. Acceptance was evaluated through the guardians using the hedonic scale and compared with the researcher’s observation. Formulations in neutral and strawberry flavors were considered acceptable for both drugs. Correlation between results from both methods was moderate for Captopril and absent for Furosemide. Neutral taste results showed that the addition of flavoring agents did not improve acceptance. Since it is recommended to avoid components in formulations for infants and newborns, unless strictly necessary, it is important to identify excipients that are dispensable.


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