Taste Receptor Tas2r5 and Tas1r3 is Expressed in Sublingual Gland
Received Date: May 14, 2018 / Accepted Date: May 21, 2018 / Published Date: May 26, 2018
Type 2 taste receptors (TAS2Rs), a large family of GPCRs, were first discovered in the gustatory system, and are co-expressed in a subset of taste receptor cells and detect bitter-tasting compounds. Type 1 taste receptors (TAS1R3) function as an obligate partner for both the umami receptor and the sweet receptor. Recently, it has become clear that taste receptors are also expressed outside the gustatory system. Here, with Tas2r5-Cre/GFP and Tas1r3-Cre/GFP transgenic mice, the expression of taste receptors (Tas1r3 or Tas2r5) is observed in serous gland and mucous gland of tongue. Taste signal transduction cascade (Gnat3 and PLC-β2) is also detected in serous gland and mucous gland of tongue. After DTA expression in Tas2r5+ and Tas1r3+ cells, the expression of taste receptors and taste signal transduction cascade is ablated in serous and mucous gland of tongue.
Keywords: Serous gland; Mucous gland; Taste receptor; Tongue; Transgenic mice
Citation: Li F, Niu B, Zhu M (2018) Taste Receptor Tas2r5 and Tas1r3 is Expressed in Sublingual Gland. Med Chem (Los Angeles) 8: 127-135. Doi: 10.4172/2161-0444.1000504
Copyright: © 2018 Li F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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