alexa Technetium-99m Labeled Fatty Acid Analogues for SPECT Imaging in Heart and Liver | OMICS International
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Short Article

Technetium-99m Labeled Fatty Acid Analogues for SPECT Imaging in Heart and Liver

Huahui Zeng1,2*, Tingting Zhang1, Fahuan Song2 and Xiangxiang Wu1*

1Pharmacy College & Scientific Research Department, Henan University of Traditional Chinese Medicine, Zhengzhou, 450046, China

2Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China

*Corresponding Author:
Huahui Zeng
Department of Nuclear Medicine
Second Hospital of Zhejiang University School of Medicine, 88 Jiefang Road
Hangzhou, Zhejiang 310009, China
Tel: 86-0571-87783659
Fax: 86-0571-87767148
E-mail:[email protected]
 
Xiangxiang Wu
Science & Technology Department
Henan University of Traditional Chinese Medicine
Jinshuidong Road Boxue Road
Zhengzhou, Henan 450008, China
Tel: 86-371-65962546
Fax: 86-371-65962546
E-mail: [email protected]

Received date: March 19, 2014; Accepted date: May 15, 2014; Published date: May 17, 2014

Citation: Zeng H, Zhang T, Song F, Wu X (2014) Technetium-99m Labeled Fatty Acid Analogues for SPECT Imaging in Heart and Liver. Med chem 4:481-486. doi: 10.4172/2161-0444.1000182

Copyright: © 2014 Zeng H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Fatty acid imaging can measure fatty acid oxidation rates in heart or liver for research applications in animals and clinical applications in humans with metabolic disorders. Recent advances in fatty acid imaging using single photon emission computed tomography (SPECT) include the wide applications of the tracer beta-methyl-p-[123I]-iodophenylpentadecanoic acid (BMIPP) to assess ischemic heart disease, cardiomyopathies, myocarditis, acute coronary syndrome, and heart failure and the design of new technetium-99m labeled tracers. In this mini-review article, several technetium-99m labeled fatty acid analogues as SPECT tracers are characterised, and the uptake of tracers, clearance from tissues, and mechanism of metabolism are discussed in detail. We subsequently summarized that some essential modification in fatty acid analogue structure can exert profound differences in the biodisposition and specificity of these tracers to improve the uptakes of fatty acids and prolong theirs retention in myocardium/hepatocyte. Thus, technetium- 99m labeled fatty acid analogues have significant potential to play an important role as clinical SPECT traces of fatty acid oxidation in cardiovascular diseases, liver, and other applications in skeletal muscle and tumors.

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