alexa Technology of High-Intensity Electric-Field Pulses: A Way to Control Protein Unfolding
ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Research Article

Technology of High-Intensity Electric-Field Pulses: A Way to Control Protein Unfolding

Paolo Marracino, Alessandra Paffi, Riccardo Reale, Micaela Liberti, Guglielmo d’Inzeo and Francesca Apollonio*
Department of Information Engineering, Electronics and Telecommunications (DIET), La Sapienza University of Rome, Italy
Corresponding Author : Francesca Apollonio, DIET
Department of Information Engineering
Electronics and Telecommunications
La Sapienza University of Rome, Via Eudossiana 18
00184, Roma, Italy
Tel: +39-06-445-85374
Fax: +39-06-445-85918
E-mail: [email protected]
Received May 03, 2013; Accepted June 25, 2013; Published June 27, 2013
Citation: Marracino P, Paffi A, Reale R, Liberti M, d’Inzeo G, et al. (2013) Technology of High–Intensity Electric–Field Pulses: A Way to Control Protein Unfolding. J Phys Chem Biophys 3:117 doi:10.4172/2161-0398.1000117
Copyright: © 2013 Marracino P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In presence of chemical, mechanical or electromagnetic stimuli, protein functions and characteristics can highly differ from physiological conditions. In this work we investigate, at atomistic details, the way in which high intensity electric field pulses can be transduced into biophysical effects mainly related to protein unfolding by comparing the effect of three different waveforms of the pulses on protein behavior. Results from molecular dynamics simulations of a globular protein, namely myoglobin, have shown that real Gaussian and Bipolar pulses with lower energy but higher spectral frequency content can induce effects similar to an ideal rectangular pulse. Index Terms-Pulsed electric fields, molecular dynamics, protein unfolding.

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