Telmisartan Protect Broiler Chickens from Pulmonary Arterial Remodeling Induced by Low Ambient Temperature
|Xue-Qin Hao1, Zhong-Min Wu2, Shou-Yan Zhang3*, Meng Li4, Tao Kong5, Cong-Fu Huang1 and Xiang-Chao Cheng6|
|1Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China|
|2Department of Anatomy, School of Medicine of Taizhou University, Taizhou, PR China|
|3Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, PR China|
|4Luoyang Entry-Exit inspection and Quarantine bureau, Luoyang, PR China|
|5Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology; Luoyang, PR China|
|6Department of veterinary Medicine, College of Animal Science and Technology, Henan University of Science and Technology; Luoyang, PR China|
|Corresponding Author :||Shouyan Zhang
Department of Cardiology
Luoyang Central Hospital Affiliated to Zhengzhou University
Luoyang, PR China.
E-mail: [email protected]
|Received March 13, 2014; Accepted April 09, 2014; Published April 19, 2014|
|Citation: Hao XQ, Wu ZM, Zhang SY, Li M, Kong T, et al. (2014) Telmisartan Protect Broiler Chickens from Pulmonary Arterial Remodeling Induced by Low Ambient Temperature. J Clin Exp Cardiolog 5:300. doi:10.4172/2155-9880.1000300|
|Copyright: © 2014 Hao XQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objective: Renin-angiotensin system is associated with many vascular diseases. This study aims to explore the protective effect of telmisartan, Angiotensin type 1 receptor blocker, on pulmonary arterial remodeling induced by low ambient temperature in broiler chickens.
Methods: Ninety chickens were randomly divided into 3 groups (n=30), including control group, low temperature group and telmisartan group. Chickens in low temperature group and telmisartan group were exposed to low ambient temperature from 14 days of age until 45 days of age; chickens in telmisartan group were gavaged with telmisartan 5 mg/kg once daily for thirty days. The pulmonary arterial systolic pressure was measured with right catheterization method. Wet lung weight index and right ventricular hypertrophy index were evaluated. Small pulmonary artery wall thickness and elastic fibers was determined respectively by H-E staining and Weight staining. Proliferating Cell Nuclear Antigen (PCNA)-positive cells were determined by Immunohistochemical staining.
Results: It showed that pulmonary arterial systolic pressure, wet lung weight index and right ventricular hypertrophy index, small pulmonary artery wall thickness, elastic fibers and PCNA expression increased significantly in Low temperature group compared with control group and telmisartan group.
Conclusion: Telmisartan can protect broiler chickens from pulmonary arterial remodeling induced by low ambient temperature